Generating mouse models for studying the function and fate of intrinsic cardiac adrenergic cells

Annals of the New York Academy of Sciences
Karl PfeiferS N Ebert

Abstract

Embryos lacking the ability to synthesize epinephrine and norepinephrine die (probably due to cardiac failure) without exogenous supplementation while mutant neonates can grow into fertile adults without supplementation. These experiments define a critical period during embryogenesis, when norepinephrine and/or epinephrine are essential for mouse development. The critical period is prior to sympathetic innervation of the heart and prior to synthesis of catecholamines by the adrenal medullae. Recent work indicates that the developing heart is likely to be a major source of catecholamines in the developing mammalian embryo. The spatial pattern of biosynthetic enzymes suggests an association of the intrinsic cardiac adrenergic cells with the developing pacemaker and cardiac conduction cells. To address the functional characteristics and the fate of these cardiac adrenergic cells, we have developed two mouse models that allow us to identify and to characterize the adrenergic cells and their descendants.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G TeitelmanD J Reis
Apr 13, 1995·Nature·S A ThomasR D Palmiter
Sep 15, 1996·The Journal of Clinical Investigation·M H HuangT W Smith
Aug 1, 1996·Journal of Molecular and Cellular Cardiology·S N EbertD L Wong
Apr 1, 1957·Journal of Cellular Physiology·E K HALL
Apr 13, 1933·The Journal of Physiology·M W Goldblatt

❮ Previous
Next ❯

Citations

Apr 20, 2007·The Journal of Obstetrics and Gynaecology Research·Seishi FurukawaBradley B Keller
Sep 17, 2004·Biochemical and Biophysical Research Communications·Laura EzquerraThomas F Deuel
May 7, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Xinyu WangWei Gao
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Aug 19, 2020·Open Biology·Alexander Grassam-RoweMing Lei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.