Generating new pancreas from old

Trends in Endocrinology and Metabolism : TEM
A A Hardikar

Abstract

Pancreas regeneration after tissue damage is a key response to pancreatic injury, involving pancreatic duct progenitor cells and intra-islet precursor cells. Surgical removal of the pancreas, duct obstruction by cellophane wrapping and bone marrow-derived stem cell transplantation act as inductive stimuli, leading to pancreas regeneration. The exact role of growth and differentiation factors regulating pancreatic beta-cell mass remains unknown. Here, I will attempt to integrate recent findings and speculate on the factors that trigger this fascinating response, wherein the pancreas responds to a deficit in cell mass and undergoes new islet formation, leading to restoration of normal beta-cell mass. I will also discuss recent advances in regenerating endocrine pancreatic cells, which could affect stem cell-based approaches to treating diabetes mellitus.

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Citations

Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ryang Hwa LeeDarwin J Prockop
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM· AnsarullahA V Ramachandran
May 12, 2007·The Review of Diabetic Studies : RDS·Meghana Kanitkar, Ramesh Bhonde
Oct 14, 2009·The Journal of Experimental Medicine·Francesca FallarinoRiccardo Calafiore
Jun 16, 2005·Trends in Molecular Medicine·Catherine M Shachaf, Dean W Felsher
Aug 12, 2009·Differentiation; Research in Biological Diversity·Vishal S ParekhAnandwardhan A Hardikar
Nov 21, 2007·Trends in Endocrinology and Metabolism : TEM·Mugdha V JoglekarAnandwardhan A Hardikar
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Mar 11, 2006·Medical Hypotheses·Julio Lazaro Padron Velazquez
Jun 15, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed Mabed
Oct 16, 2007·Developmental Biology·Mugdha V JoglekarAnandwardhan A Hardikar
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·E FernándezC Alvarez

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