Generating probabilistic Boolean networks from a prescribed transition probability matrix

IET Systems Biology
W-K ChingN-K Tsing

Abstract

Probabilistic Boolean networks (PBNs) have received much attention in modeling genetic regulatory networks. A PBN can be regarded as a Markov chain process and is characterised by a transition probability matrix. In this study, the authors propose efficient algorithms for constructing a PBN when its transition probability matrix is given. The complexities of the algorithms are also analysed. This is an interesting inverse problem in network inference using steady-state data. The problem is important as most microarray data sets are assumed to be obtained from sampling the steady-state.

References

Mar 1, 1969·Journal of Theoretical Biology·S A Kauffman
Jul 15, 2000·Neuron·P SmolenJ H Byrne
Sep 10, 2005·Bioinformatics·Ranadip PalEdward R Dougherty
Sep 28, 2005·International Journal of Neural Systems·Wai-Ki ChingTatsuya Akutsu
Oct 31, 2006·Journal of Theoretical Biology·Tatsuya AkutsuMichael K Ng
May 9, 2008·Journal of Biomedical Informatics·Ying Zhang, Peter Szolovits
Mar 26, 2009·Methods : a Companion to Methods in Enzymology·Kim SerdonsGuy M Bormans
May 30, 2009·Preventive Veterinary Medicine·Catherine A AlinoviChing Ching Wu

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Citations

Jul 3, 2013·Cell Communication and Signaling : CCS·Panuwat TrairatphisanThomas Sauter
Jun 14, 2016·IEEE Transactions on Neural Networks and Learning Systems·Koichi Kobayashi, Kunihiko Hiraishi

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