Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Stem Cells International
Chengzhu Zhao, Makoto Ikeya

Abstract

Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number of publications and clinical trials have highlighted their potential in regenerative medicine. However, the finite proliferative capacity of MSCs limits their scalability and global dissemination as a standardized therapeutic product. Furthermore, adult tissue provenance could constrain accessibility, impinge on cellular potency, and incur greater exposure to disease-causing pathogens based on the donor. These issues could be circumvented by the derivation of MSCs from pluripotent stem cells. In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC applications to disease modeling, pathogenic mechanisms, and drug discovery. We also discuss the potential applications of MSCs in regenerative medicine including cell-based therapies and issues that should be overcome before iPSC-derived MSC therapy will be applied in the clinic.

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Citations

Apr 21, 2019·International Journal of Molecular Sciences·Ahmed Abdal DayemAnd Ssang-Goo Cho
Sep 29, 2019·Andrology·A Gauthier-FisherC L Librach
Aug 29, 2020·International Journal of Molecular Sciences·Clara Sanjurjo-RodríguezSilvia Díaz-Prado
Mar 20, 2019·Stem Cell Research & Therapy·Lucas-Sebastian SpitzhornJames Adjaye
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Oct 10, 2020·World Journal of Stem Cells·Qing-Shu MengXiao-Ting Liang
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Feb 16, 2021·Frontiers in Cell and Developmental Biology·Asim Cengiz AkbulutLeon J Schurgers
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Samantha E Spellicy, David C Hess
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Soudeh Ghafouri-FardAbbas Basiri
Oct 5, 2021·Frontiers in Cell and Developmental Biology·Wasco WruckJames Adjaye

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