Generation and Assessment of Functional Biomaterial Scaffolds for Applications in Cardiovascular Tissue Engineering and Regenerative Medicine

Advanced Healthcare Materials
Svenja HindererKatja Schenke-Layland

Abstract

Current clinically applicable tissue and organ replacement therapies are limited in the field of cardiovascular regenerative medicine. The available options do not regenerate damaged tissues and organs, and, in the majority of the cases, show insufficient restoration of tissue function. To date, anticoagulant drug-free heart valve replacements or growing valves for pediatric patients, hemocompatible and thrombus-free vascular substitutes that are smaller than 6 mm, and stem cell-recruiting delivery systems that induce myocardial regeneration are still only visions of researchers and medical professionals worldwide and far from being the standard of clinical treatment. The design of functional off-the-shelf biomaterials as well as automatable and up-scalable biomaterial processing methods are the focus of current research endeavors and of great interest for fields of tissue engineering and regenerative medicine. Here, various approaches that aim to overcome the current limitations are reviewed, focusing on biomaterials design and generation methods for myocardium, heart valves, and blood vessels. Furthermore, novel contact- and marker-free biomaterial and extracellular matrix assessment methods are highlighted.

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Citations

Dec 15, 2015·Advanced Drug Delivery Reviews·Svenja HindererKatja Schenke-Layland
Mar 8, 2016·Current Opinion in Biotechnology·Michael G MonaghanKatja Schenke-Layland
Dec 16, 2017·Materials·Saeid KargozarFrancesco Baino
Sep 6, 2018·Nature Reviews. Cardiology·Elvira ForteNadia Rosenthal

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Methods Mentioned

BETA
homografts
xenografts
atomic force micro­scopy
PCRs
irradiate
X‐ray
nuclear magnetic resonance
light microscopy
confocal microscopy
genetic modifications

Software Mentioned

FLIM

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