Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2.

Hybridoma
Sarah A KeimJames K Wahl

Abstract

Abstract Cadherins are synthesized with a signal sequence and a proregion that must be removed for optimal adhesive activity. Mutations that prevent processing of cadherins have been implicated in a number of human diseases; thus understanding their processing is critical. In this study, we produced and characterized a number of monoclonal antibodies against the proregion of the desmosomal cadherin, human desmoglein-2, that will facilitate investigations into the processing of this protein.

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Citations

Dec 15, 2010·Nature Medicine·Hongjie WangAndré Lieber
Nov 2, 2014·Journal of Cellular Physiology·Lihua HuAli Nawshad
Oct 23, 2016·Oncotarget·Andrew M OvermillerMỹ G Mahoney
Apr 26, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew M OvermillerMỹ G Mahoney
Apr 15, 2015·Oncotarget·Donna M Brennan-CrispiMỹ G Mahoney
Feb 25, 2017·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Xiaorui LiYu Liu

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