PMID: 11326891May 1, 2001Paper

Generation and prediction of hypoxemia in patients with chronic obstructive pulmonary disease

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
W WangQ Wang

Abstract

To study the pathogenesis of nocturnal hypoxemia in patients with chronic obstructive pulmonary disease (COPD). Daytime pulmonary functions, arterial blood gases and nocturnal oxygen level were measured in 30 patients and compared with those of 8 normal subjects. The nocturnal oxygen level significantly decreased in patients with COPD compared with that in normal subjects, especially during rapid eye movement (REM) period. The decreased extents of nocturnal mean oxyhemoglobin saturation (MSaO2) and nocturnal minimum oxyhemoglobin saturation (MmSaO2) were also very high in COPD (P < 0.05). From the distribution of oxyhemoglobin, the percentage of the time that oxyhemoglobin saturation (SaO2) < 80% and < 90% during sleep (T80, T90) in patients were found higher than those in normal subjects (P < 0.05). The sleep time in which SaO2 below 90 percent obviously increased in COPD patients. The correlative analysis indicated that daytime SaO2 and FEV1% were related to the nocturnal mean oxyhemoglobin saturation (r = 0.79, 0.54). So predictive formula of nocturnal oxyhemoglobin level was derived as follows: MSaO2(%) = 1.03 x SaO2(%) + 0.19 x FEV1%(%) - 14.35(r = 0.83). Daytime SaO2 and PaCO2 were also found concerned with nocturnal oxyg...Continue Reading

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