Generation of a human induced pluripotent stem cell (iPSC) line from a 51-year-old female with attention-deficit/hyperactivity disorder (ADHD) carrying a duplication of SLC2A3

Stem Cell Research
Charline JanschKlaus-Peter Lesch

Abstract

Fibroblasts were isolated from a skin biopsy of a clinically diagnosed 51-year-old female attention-deficit/hyperactivity disorder (ADHD) patient carrying a duplication of SLC2A3, a gene encoding neuronal glucose transporter-3 (GLUT3). Patient fibroblasts were infected with Sendai virus, a single-stranded RNA virus, to generate transgene-free human induced pluripotent stem cells (iPSCs). SLC2A3-D2-iPSCs showed expression of pluripotency-associated markers, were able to differentiate into cells of the three germ layers in vitro and had a normal female karyotype. This in vitro cellular model can be used to study the role of risk genes in the pathogenesis of ADHD, in a patient-specific manner.

Citations

May 8, 2020·Journal of Neural Transmission·Rhiannon V McNeillSarah Kittel-Schneider
May 7, 2020·Journal of Cellular Physiology·Georg C ZieglerKlaus-Peter Lesch
Feb 10, 2021·Journal of Neural Transmission·Charline JanschKlaus-Peter Lesch
Jul 4, 2021·The International Journal of Neuropsychopharmacology·Jakob UnterholznerRupert Lanzenberger

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