Generation of amyloidogenic C-terminal fragments during rapid axonal transport in vivo of beta-amyloid precursor protein in the optic nerve.

The Journal of Biological Chemistry
A Amaratunga, R Fine

Abstract

The amyloid beta-protein (A beta) is a major component of extracellular deposits that are characteristic features of Alzheimer's disease. A beta is derived from the large transmembrane beta-amyloid precursor protein (beta APP). In the rabbit optic nerve/optic tract (ON), beta APP is synthesized in vivo in retinal ganglion cell perikarya, rapidly transported into the ON axons in small transport vesicles and is subsequently transferred to the axonal plasma membrane as well as to the presynaptic nerve terminals (Morin, P. J., Abraham, C. R., Amaratunga, A., Johnson, R.J., Huber, G., Sandell, J. H., and Fine, R. E. (1993) J. Neurochem. 61, 464-473). Present results indicate that there is rapid processing of beta APP in the ON to generate a 14-kDa C-terminal membrane-associated fragment that contains the A beta sequence. By using equilibrium sucrose density gradient fractionation, this fragment, as well as non-amyloidogenic C-terminal fragments and intact beta APP, are detected in at least two classes of transport vesicles destined for the plasma membrane and the presynaptic nerve terminal. The two classes of transported vesicles are distinguished by labeling kinetics as well as by density. In contrast to the ON, only nonamyloidogen...Continue Reading

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Citations

Aug 12, 1998·Journal of Molecular Neuroscience : MN·K M Sheridan, W A Maltese
Aug 13, 2009·Journal of Ocular Biology, Diseases, and Informatics·Zhiqun Tan
Jan 5, 2010·Journal of Ocular Biology, Diseases, and Informatics·Zhiqun Tan
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Oct 12, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V ParisiF Pierelli
Mar 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Virgil MuresanZoia Muresan
Apr 20, 2004·Journal of Cellular and Molecular Medicine·Kristina SennvikE Benedikz
Apr 2, 2013·Nutritional Neuroscience·Pinar Erkekoglu, Terken Baydar
Jan 13, 2015·Experimental Cell Research·Virgil Muresan, Zoia Ladescu Muresan
Jun 30, 2006·Journal of Neurochemistry·Donald A SiegelMay Huang
May 5, 2018·Journal of Cell Science·María Gabriela OteroTomás Luis Falzone
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Feb 7, 2006·Journal of Physiology, Paris·Gorazd B Stokin, Lawrence S B Goldstein

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