PMID: 9437248Oct 1, 1994Paper

Generation of contractile force by cultured Dupuytren's disease and normal palmar fibroblasts

Tissue & Cell
G M Rayan, J J Tomasek

Abstract

Contractile fibroblasts are believed to be responsible for palmar fascia contracture in Dupuytren's Disease. An in vitro collagen lattice model was used to examine the contractile properties of Dupuytren's fibroblasts from 10 patients undergoing partial fasciectomy, and palmar fascia fibroblasts from 6 patients undergoing carpel tunnel release. Dupuytren's and palmar fascia fibroblasts cultured within a stabilized collagen lattice acquired morphological characteristics similar to those of 'myofibroblasts' in Dupuytren's diseased fascia. Both types of fibroblasts generated contractile forces that resulted in rapid collagen lattice contraction after release of the lattice from points of stabilization. Generation of contractile force by the fibroblasts was inhibited by disruption of the actin cytoskeleton, lack of cells, or serum removal. Afferent neuropeptides (substance P, galanin and neurokinin A) did not promote lattice contraction. These results demonstrate that normal palmar fascia fibroblasts can modulate into Dupuytren's-like fibroblasts and that cultured fibroblasts, from either Dupuytren's diseased or normal palmar fascia, can generate contractile forces that are transmitted to extracellular matrix. In addition, fibrobla...Continue Reading

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Citations

May 11, 2005·Archives of Dermatological Research·Céline ViennetPhilippe Humbert
Jun 2, 2012·Hand : Official Journal of the American Association for Hand Surgery·Josef G HadeedHoward Levinson
Jul 11, 2001·Journal of Cardiovascular Pharmacology·P J LijnenR H Fagard
Oct 5, 2010·The Journal of Hand Surgery·Issei KomatsuHoward Levinson
Nov 17, 2009·The Journal of Hand Surgery·Liaquat Suleman VerjeeJagdeep Nanchahal
Mar 6, 2007·The Journal of Hand Surgery·Phillip JohnstonIan M Clark
Sep 12, 2013·Case Reports in Neurological Medicine·Baiba LaceEriks Jankevics
Sep 19, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jennifer S N VerhoekxVivek Mudera
Sep 27, 2005·The Journal of Hand Surgery·Ghazi M Rayan
Feb 22, 2012·Biochimica Et Biophysica Acta·Janine M WilkinsonIan M Clark
Apr 2, 2002·The Journal of Surgical Research·M Ann KuhnMartin C Robson
May 4, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M ForsmanJ Ryhänen
Nov 1, 1996·The Journal of Hand Surgery·G M RayanJ J Tomasek

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