Generation of dynamic chemical signals with microfluidic C-DACs

Lab on a Chip
L ChenC H Mastrangelo

Abstract

The utilization of microfluidic "lab-on-a-chip" devices in fundamental medical research, drug discovery and clinical diagnostics has rapidly increased in the past decade. Lab-on-a-chip devices process small volumes of analytes and reagents through on-chip microfluidic signal processing circuits. This paper discusses the implementation of a basic microfluidic circuit block, the concentration digital-to-analog converter (or C-DAC) which produces discretized chemical concentrations in a constant stream of solvent. The chemical concentration is controlled by a time-varying digital word; hence C-DACs are suitable for on-chip generation of arbitrary chemical signals. A 4-bit continuous-flow C-DAC was fabricated in two-level PDMS technology and tested. Several chemical waveforms (sawtooth, cosine, and ramp) were generated at flow rates of 2 microL min(-1) and frequencies of 0.6-4 mHz. The frequency cut off of this C-DAC was approximately 500 mHz.

References

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Citations

May 11, 2010·Annual Review of Biomedical Engineering·Daniel Irimia
Apr 25, 2008·Lab on a Chip·Y XieC H Mastrangelo
May 24, 2008·Lab on a Chip·F Azizi, C H Mastrangelo
Jun 5, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Andreja JovicShuichi Takayama
Oct 1, 2008·Expert Opinion on Drug Discovery·Yuan Wen, Shang-Tian Yang
Dec 25, 2008·Lab on a Chip·Eujin Um, Je-Kyun Park
Dec 20, 2011·Lab on a Chip·Kwang W OhEdward P Furlani
Jun 3, 2017·Lab on a Chip·Andreas PiehlerSavaş Tay
May 24, 2008·Analytical Chemistry·Jonathan WestAndreas Manz
May 30, 2009·Analytical Chemistry·Alar AinlaAldo Jesorka
Jun 24, 2010·Analytical Chemistry·Layne D WilliamsCarlos H Mastrangelo
Aug 10, 2017·Analytical Chemistry·Peng ChenBi-Feng Liu

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