Generation of effector cells from T cell subsets. II. Lyt 123 T cells contain the precursors for all primary cytotoxic effector cells and for cells involved in the regulation of cytotoxic responses

European Journal of Immunology
M M Simon, B Abenhardt

Abstract

Mixed responder populations, consisting of selected Lyt-2,3+ cells and unselected T cells from two congenic mouse strains differing in their Lyt-2,3 alleles, were used to study the role of Lyt-1,2,3+ cells in the generation of cytotoxic effector cells in vitro. The fact that, under these conditions, all primary alloreactive and H-2-restricted killer cells ar generated from the unselected T cell population and not from the selected Lyt-2,3+ subset is demonstrated. Isolated, unsensitized Lyt-2,3+ cells are able to produce primary alloreactive cytotoxic T lymphocytes (CTL) when incubated with alloantigen alone, but appear to be suppressed in the pesence of Lyt-1,2,3+ cells. In contrast, mixtures of Lyt-2,3+ cells selected from C57BL/6 T cells previously primed to alloantigen in vitro, and unselected T cells from the Lyt-2,3-congenic partner after exposure to the same antigen give rise to cytotoxic effector cells which derive mainly from the primed Lyt-2,3+ cell pool and not from the unselected T cell population. Both populations were able to generate CTL when sensitized separately with the alloantigen. The data suggest that Lyt-1,2,3+ cells contain all primary precursors for both H-2 restricted and alloreactive killer cells, as we...Continue Reading

References

Sep 1, 1978·The Journal of Experimental Medicine·F H Bach, B J Alter
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R FinbergB Benacerraf
Jan 1, 1977·Immunological Reviews·H Cantor, E A Boyse
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H Cantor, E A Boyse
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·O StutmanE A Boyse
Jun 11, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·E A BoyseL J Old

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Citations

Sep 1, 1982·The Journal of Experimental Medicine·M S SyR Finberg
Aug 1, 1986·Kidney International·E G NeilsonR Mann

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