Generation of excitatory postsynaptic potentials in the hippocampus after functional modification of glycosaminoglycans

Bulletin of Experimental Biology and Medicine
Yu S GarkunV A Kulchitsky

Abstract

Experiments on hippocampal slices form 4-week-old rats (n=28) showed that addition of lidase (1.0 and 10.0 U/ml) to the perfusion solution (artificial cerebrospinal fluid) was accompanied by the impaired generation or blockade of excitatory postsynaptic potentials and population spikes in the hippocampal CA1 region during stimulation of Schaffer collaterals. Removal of lidase from this solution normalized the amplitude of evoked responses. Hence, lidase in these concentrations produced a reversible effect on synaptic transmission. Our results indicate that structure and function of glycosaminoglycans in the extracellular matrix determine signal transduction in the nervous tissue.

References

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Citations

Aug 1, 2008·Neuron Glia Biology·Renato Frischknecht, Constanze I Seidenbecher
Apr 26, 2014·Cellular & Molecular Biology Letters·Vladimir I PotkinVladimir A Kulchitsky

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