PMID: 6166007Apr 1, 1981Paper

Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type

Proceedings of the National Academy of Sciences of the United States of America
R DulbeccoM Unger

Abstract

We have isolated clonal cell lines from a nitrosomethylurea-induced mammary tumor in Wistar--Furth rats. The epithelial-like cells of these lines give rise to fibroblast-like cells. A study of several markers showed that the epithelial-like cells are similar to epithelial mammary cells. The fibroblastic cells, however, were similar to stromal cells, except for the production of collagen IV. The events occurring in these cultures are identical to those observed in previously isolated mammary cultures [Bennett, D. C., Peachey, L. A., Durbin, H. & Rudland, P. S. (1976) Cell 15, 283--298], suggesting their generality. The fibroblast-like cells generated in culture may be a hitherto unrecognized type of mammary cell.

References

Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V A LennonR Dulbecco
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoM Unger
Jun 1, 1979·The Journal of Cell Biology·W W FrankeK Weber
Sep 1, 1978·Cell·D C BennettP S Rudland
Sep 1, 1973·Transplantation·F Listing
Mar 1, 1980·The Journal of Cell Biology·W W FrankeT W Keenan
Jan 1, 1980·Annual Review of Biochemistry·P Bornstein, H Sage

❮ Previous
Next ❯

Citations

Jan 1, 1983·Cancer Metastasis Reviews·G H Heppner, B E Miller
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·M GuarinoG Micoli
Jan 1, 1984·Breast Cancer Research and Treatment·M Stoker, M Perryman
Jan 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·P S RudlandM J Warburton
May 1, 1992·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E Hellmén
Jul 15, 1994·Cancer Genetics and Cytogenetics·M E HerrmannP A Lalley
Nov 1, 1995·Cancer Genetics and Cytogenetics·M E HerrmannG B Talpos
Apr 1, 1991·Molecular and Cellular Endocrinology·J CocletP P Roger
Jan 1, 1985·Biochimica Et Biophysica Acta·J M Vasiliev
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R DulbeccoP Syka
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A M VallésJ P Thiery
May 1, 1993·Histopathology·M GuarinoB Forloni
Mar 1, 1989·Environmental Health Perspectives·R Barraclough, P S Rudland
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H M KamelP G Toner
Apr 1, 1993·Genes, Chromosomes & Cancer·M E Herrmann, K T Trevor
Nov 1, 1995·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·M Guarino, F Giordano
Oct 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E D Hay, A Zuk
Jan 16, 2007·Stem Cells·Yoko KoideYumi Matsuzaki
Mar 1, 1991·Differentiation; Research in Biological Diversity·B H LiptonM A Karasek
Apr 1, 1991·Differentiation; Research in Biological Diversity·M J O'HareB A Gusterson
May 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M StokerR Eeles
Jan 1, 1982·Journal of Cellular Physiology. Supplement·R Dulbecco
Sep 1, 1989·American Journal of Medical Genetics·E D Hay
Feb 15, 1987·International Journal of Cancer. Journal International Du Cancer·D J DunningtonG Poste
Dec 15, 1989·International Journal of Cancer. Journal International Du Cancer·E M Rivera, B Alston-Mills
Jun 1, 1991·Journal of Virology·R JavierT Shenk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.