Generation of genetically-engineered animals using engineered endonucleases

Archives of Pharmacal Research
Jong Geol LeeIn-Jeoung Baek

Abstract

The key to successful drug discovery and development is to find the most suitable animal model of human diseases for the preclinical studies. The recent emergence of engineered endonucleases is allowing for efficient and precise genome editing, which can be used to develop potentially useful animal models for human diseases. In particular, zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeat systems are revolutionizing the generation of diverse genetically-engineered experimental animals including mice, rats, rabbits, dogs, pigs, and even non-human primates that are commonly used for preclinical studies of the drug discovery. Here, we describe recent advances in engineered endonucleases and their application in various laboratory animals. We also discuss the importance of genome editing in animal models for more closely mimicking human diseases.

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Citations

May 23, 2019·Médecine sciences : M/S·Hélène Hardin-Pouzet, Serban Morosan
Feb 24, 2019·Scientific Reports·Jong Geol LeeIn-Jeoung Baek
Oct 12, 2018·Metallomics : Integrated Biometal Science·C Abbehausen
Jul 30, 2020·Archives of Pharmacal Research·Chang K Sung, Hyungshin Yim
Jan 10, 2021·Biochemical and Biophysical Research Communications·Seak Hee OhYoung Hoon Sung
Jan 12, 2021·Frontiers in Nutrition·Cyril PoupetStéphanie Bornes

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Methods Mentioned

BETA
transgenic
gene knockout

Software Mentioned

TALE

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