PMID: 9534005Apr 16, 1998Paper

Generation of glucose-dependent slow oscillations of cytoplasmic Ca2+ in individual pancreatic beta cells

Diabetes & Metabolism
E GylfeM Eberhardson

Abstract

Individual pancreatic beta cells respond to glucose stimulation with large amplitude (300-500 nM) oscillations in the cytoplasmic Ca2+ concentration ([Ca2+]i). These oscillations (frequency 0.05-0.5/min) depend on rhythmical depolarization of the plasma membrane, with influx of Ca2+ through voltage-operated channels, but do not require intracellular mobilization of Ca2+. Patch clamp analyses of the activity of ATP-sensitive K+ channels indicate that oscillations in beta-cell metabolism underlie the rhythmical depolarizations, causing the large amplitude oscillations of [Ca2+]. The oscillatory responses of adjacent beta cells are synchronized by gap-junctional coupling in cellular microdomains. With increasing glucose concentration, previously unresponsive domains are activated, and their oscillations entrained with those of other active domains. In pancreatic islets, glucose-induced large amplitude oscillations occur in parallel with insulin release pulses, the amplitudes of which are determined by the number of beta cells recruited into the secretory state.

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Related Papers

American Journal of Physiology. Heart and Circulatory Physiology
Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
The Biochemical Journal
Jackson C Kirkman-BrownStephen J Publicover
© 2022 Meta ULC. All rights reserved