Generation of High Dose Inhalable Effervescent Dispersions against Pseudomonas aeruginosa Biofilms

Pharmaceutical Research
Aram MohammedHisham Al-Obaidi

Abstract

Novel particle engineering approach was used in this study to generate high dose inhalable effervescent particles with synergistic effects against Pseudomonas aeruginosa biofilms. Spray dried co-amorphous salt of ciprofloxacin (CFX) and tartaric acid (TA) was prepared and coated with external layer of sodium bicarbonate and silica coated silver nanobeads. Design of experiments (DOE) was used to optimize physicochemical properties of particles for enhanced lung deposition. Generated particles were co-amorphous CFX/TA showing that CFX lost its zwitterionic form and exhibiting distinct properties to CFX/HCl as assessed by FTIR and thermal analysis. Particles exhibited mass mean aerodynamic diameter (MMAD) of 3.3 μm, emitted dose of 78% and fine particle dose of 85%. Particles were further evaluated via antimicrobial assessment of minimum inhibitory concentrations (MIC) and minimum biofilm eradication concentration (MBEC). MIC and MBEC results showed that the hybrid particles were around 3-5 times more effective when compared to CFX signifying that synergistic effect was achieved. Diffusing wave spectroscopy results showed that the silver containing particles had a disruptive effect on rheological properties as opposed to silver fr...Continue Reading

References

Nov 28, 2007·Pharmaceutical Research·Reinhard Vehring
Oct 21, 2009·AAPS PharmSciTech·Hisham Al-Obaidi, Graham Buckton
Aug 11, 2011·International Journal of Pharmaceutics·Ning QiaoGary Trappitt
Jun 28, 2012·Sensors·Yung-Hua Li, Xiaolin Tian
Sep 22, 2012·Biophysical Journal·Olivier GalyNelly Henry
Dec 5, 2012·International Journal of Pharmaceutics·Ranjit ThakuriaNaír Rodríguez-Hornedo
Dec 5, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sarah ClausWolfgang Friess
Apr 17, 2014·Advanced Drug Delivery Reviews·M HoppentochtA H de Boer
Apr 17, 2014·Advanced Drug Delivery Reviews·Anne Marie HealyLidia Tajber
Jun 16, 2014·Respiratory Medicine·Pascal DemolyHenderik W Frijlink
Jun 30, 2014·Applied Microbiology and Biotechnology·Maisem LaabeiA Tobias A Jenkins
Mar 1, 2015·FEMS Microbiology Reviews·Brandon W PetersonHenk J Busscher
Aug 22, 2015·Journal of Pharmaceutical Sciences·Jeffry G Weers, Danforth P Miller
Sep 15, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Héctor RudillaMiguel Viñas
Oct 5, 2016·Scientific Reports·Yan-Zhen ZhengRong-Cai Lai
Jun 2, 2017·Molecular Pharmaceutics·Hanah MesallatiLidia Tajber
Jan 27, 2018·American Journal of Respiratory Cell and Molecular Biology·Nicholas M MauriceRuxana T Sadikot
Apr 15, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hisham Al-ObaidiMohammed Gulrez Zariwala

❮ Previous
Next ❯

Methods Mentioned

BETA
X-Ray
Differential Scanning Calorimetry
Infrared Spectroscopy
Diffusing Wave Spectroscopy
Assay

Software Mentioned

DFFRAC plus XRD
JASP

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Related Papers

Toxicological Sciences : an Official Journal of the Society of Toxicology
Unni Cecilie NygaardMartinus Løvik
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Leticia ElyRaimar Lobenberg
Journal of Controlled Release : Official Journal of the Controlled Release Society
G Owusu-AbabioH Anwar
Risk Analysis : an Official Publication of the Society for Risk Analysis
H Ozkaynak, G D Thurston
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Saber Naderi, Paul van der Schoot
© 2021 Meta ULC. All rights reserved