Generation of HLA-B*1516/B*1567/B*1595 and B*1517 alleles (B15 specific group) by transpecies evolution

Human Immunology
Angela RománJ Martínez-Laso

Abstract

The generation of the human leukocyte antigen (HLA)-B*1516, B*1517, B*1567, and B*1595 alleles has been analyzed using exon 1, intron 1, exon 2, intron 2, and exon 3 sequences from human and non-human primates. Results showed that at the first place three evolutionary steps would have been necessary for the generation of HLA-B*1516 and B*1517 alleles: (1) a non-human primate step with the generation of a major histocompatibility complex (MHC)-B*1516/1517-like allele; (2) a human or non-human primate step with two different ways of evolution generating a MHC-B*1516 and a MHC-B*1517 ancestors; and (3) a human step consisting of the generation of HLA-B*1516 and HLA-B*15170101 alleles. After that, HLA-B*1567, B*1595 B*151701012, and B*151702 alleles would be generated by point mutation events. In conclusion these alleles are generated by two different evolutionary pathways. The generation of these alleles points out the importance of the exons/introns in the generation of the evolution of HLA alleles.

References

Sep 1, 1997·Immunogenetics·G Vargas-AlarcónA Arnaiz-Villena
Jan 6, 2001·Tissue Antigens·K W LeeJ Y Park
Jan 10, 2003·Nucleic Acids Research·James RobinsonSteven G E Marsh
Feb 27, 2004·Immunogenetics·Jorge Martinez-LasoAntonio Arnaiz-Villena
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Mar 25, 2005·International Journal of Immunogenetics·S G E MarshJ Trowsdale
Feb 3, 2006·Tissue Antigens·J Martínez-LasoA Arnaiz-Villena
Dec 21, 2006·Tissue Antigens·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System

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Citations

Mar 8, 2011·Human Immunology·Jorge Martínez-LasoIsabel Cervera
May 21, 2008·Tissue Antigens·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Apr 2, 2010·Tissue Antigens·S G E MarshJ Trowsdale

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