Generation of hydroxyl radicals during ascites experimentally induced in broilers

British Poultry Science
H A ArabMohammad Hassanzadeh

Abstract

Increased metabolic rates, pulmonary hypertension and cardiac dysfunction are the most important features of the ascites syndrome in broiler chickens. However, the mechanism of cell injury causing the pathogenesis of the syndrome is not clearly understood. Our study aimed to examine the generation of hydroxyl radicals (OH*) in broiler chickens experiencing ascites. The hundred and fifty 1-d-old chickens were purchased from a local hatchery and reared in an open poultry house for 46 d. They were divided at random into three groups and ascites was induced in two groups by exposing them to low temperature or administration of triiodothyronine (T(3)). The third group served as control and was reared normally. Haematological, biochemical and pathological tests were used to determine the incidence of ascites: including total red blood cell (RBC), packed cell volume (PCV), release of alanine transaminase (ALT) and aspartate transaminase (AST) and ratio of right ventricular weight to total ventricular weight (RV/TV). A salicylate hydroxylation method was used to examine the generation of hydroxyl radicals (OH*) in treated groups. TWo hydroxylated salicylic acid metabolites, 2,3- and 2,5-dihydroxy benzoic acid (2,3- and 2,5-DHBA), were ...Continue Reading

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Citations

Oct 30, 2010·Research in Veterinary Science·Hossein HassanpourBehzad Heydaripoor
Jul 9, 2009·Acta Veterinaria Hungarica·Hossein HassanpourHamed Zarei
Nov 4, 2017·Journal of Animal Physiology and Animal Nutrition·Z-P LvY-M Guo
Jun 17, 2021·Veterinary Medicine and Science·Behnam AhmadipourFariborz Khajali
Jul 23, 2021·Journal of Animal Physiology and Animal Nutrition·Mohammad KamelyTheo Niewold

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