PMID: 6972994Apr 1, 1981Paper

Generation of idiotype-specific T cell help through network perturbation

The Journal of Experimental Medicine
K GleasonH Köhler

Abstract

Different manipulations of BALB/c mice were used to generate idiotype-specific help: neonatally induced suppression of the T 15 idiotype and low-dose priming with anti-T15 antibody. The splenic foci culture system was used to study T15-idiotype-recognizing helper T cells under limiting-cell-dose conditions. These treatments induced T15 idiotype-specific help for B cells responding to TNP-T15. Normal or hemocyanin-primed BALB/c mice did not supply T15 idiotype-specific help. The helper cells were sensitive to anti-Thy-1.2 and complement treatment and can distinguish T15 from an idiotype-different, PC-binding myeloma protein, M167, and the TNP binding myeloma protein, M460. These data show that idiotype-specific T helper cells can be induced by at least two different manipulations of the idiotype network. These manipulations presumably do not act directly on the T15-recognizing T cells, but must involve complementary idiotypic circuits that stimulate anti-T15 specific T cells. Furthermore, this study demonstrates that the splenic-fragment culture technique provides a general method to investigate, at the single cell level, idiotypic T-B cell interactions induced by perturbations of the immune network.

References

Nov 1, 1975·The Journal of Experimental Medicine·E Trenkner, R Riblet
Oct 1, 1976·The Journal of Experimental Medicine·D A RowleyI Lorbach
Jul 1, 1976·European Journal of Immunology·A Augustin, H Cosenza
May 1, 1977·European Journal of Immunology·H CosenzaM H Julius
Jul 1, 1978·European Journal of Immunology·M H JuliusA A Augustin
Apr 1, 1979·The Journal of Experimental Medicine·H BinzH Wigzell
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L J Wysocki, V L Sato
Aug 1, 1972·The Journal of Experimental Medicine·N R Klinman
Dec 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L Kluskens, H Köhler
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Cosenza, H Köhler
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jun 1, 1972·The Journal of Experimental Medicine·D A HartA Nisonoff

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Citations

Sep 29, 1999·Immunology Today·R Hooghe, E L Hooghe-Peters
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R Z DintzisH M Dintzis
Oct 1, 1981·The Journal of Experimental Medicine·S K PierceH Köhler
Sep 1, 1983·The Journal of Experimental Medicine·M McNamara, H Kohler
Dec 1, 1983·The Journal of Experimental Medicine·E K Bikoff
Dec 1, 1984·American Journal of Reproductive Immunology : AJRI·D P SingalS Joseph
Jan 1, 1983·Annals of the New York Academy of Sciences·S K Pierce, N A Speck
Jan 1, 1983·Annals of the New York Academy of Sciences·M McNamaraH Kohler
Jun 1, 1984·Immunological Reviews·M McNamaraH Kohler
May 1, 1985·Clinical Immunology and Immunopathology·A R Pachner, F S Kantor
Jul 1, 1985·European Journal of Immunology·E Becker Dunn, K Bottomly
Jan 30, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Heinz Kohler, Srini Kaveri

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