PMID: 2507725Oct 1, 1989Paper

Generation of immunoglobulin heavy chain diversity subsequent to cell surface immunoglobulin expression in the avian bursa of Fabricius

The Journal of Experimental Medicine
M J Ratcliffe

Abstract

The avian bursa of Fabricius represents a site for the generation of antibody diversity. Transfer of neonatal bursal cells into cyclophosphamide-treated neonatal chickens results in reconstitution of recipient bursae with donor-derived bursal stem cells. These stem cells express cell surface IgM and, under conditions of limiting donor bursal stem cell numbers, each reconstituted bursal follicle is colonized by a single precursor cell. The expression of an Ig VH idiotype, CVH-1, was found to be heterogenous within such clonal follicles. The diversity generated within the bursa is subsequently found within the peripheral B cell compartment. Thus, the generation of functional Ig H chain diversity is shown to occur subsequent to Ig H chain rearrangement and expression.

References

Jul 1, 1976·The Journal of Experimental Medicine·P M LydyardM D Cooper
Jun 1, 1988·European Journal of Immunology·O LassilaJ R Pink
Jun 1, 1986·Immunological Reviews·J R Pink
Jan 1, 1985·European Journal of Immunology·J R PinkA M Rijnbeek
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P W KincadeM D Cooper

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Citations

Aug 1, 1991·The Journal of Experimental Medicine·E HoussaintO Vainio
Mar 24, 2015·Current Opinion in Immunology·Alessandra GranatoDuane R Wesemann
Sep 8, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·T IijimaM Noguchi
Feb 1, 1994·European Journal of Immunology·E Paramithiotis, M J Ratcliffe
Jan 1, 1993·European Journal of Immunology·E Paramithiotis, M J Ratcliffe
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C E Sayegh, M J Ratcliffe
Feb 1, 1991·European Journal of Immunology·A Veillette, M J Ratcliffe

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