PMID: 9535655May 2, 1998Paper

Generation of intestinal T cells from progenitors residing in gut cryptopatches

Science
H SaitoH Ishikawa

Abstract

Cryptopatches (CPs) are part of the murine intestinal immune compartment. Cells isolated from CPs of the small intestine that were c-kit positive (c-kit+) but lineage markers negative (Lin-) gave rise to T cell receptor (TCR) alphabeta and TCR gammadelta intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit+Lin- cells, failed to do so. These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.

References

Aug 1, 1994·The Journal of Experimental Medicine·B RochaD Guy-Grand
Apr 1, 1996·European Journal of Immunology·A RegnaultP Kourilsky
Apr 1, 1996·The Journal of Experimental Medicine·K FujihashiH Kiyono
Mar 28, 1997·Science·J WangJ R Klein
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney

❮ Previous
Next ❯

Citations

Dec 18, 2001·European Journal of Immunology·J Woodward, E Jenkinson
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S YamamotoT Abo
Dec 21, 2004·Springer Seminars in Immunopathology·Peter VelázquezJonathan Braun
Dec 16, 2000·Springer Seminars in Immunopathology·C MillerA C Hayday
Dec 16, 2000·Springer Seminars in Immunopathology·D A WitherdenW L Havran
Nov 2, 2005·Journal of Gastroenterology·Osamu HitotsumatsuHiromichi Ishikawa
Mar 16, 2005·Current Opinion in Immunology·Daniela Finke
Nov 15, 2002·Molecular Immunology·James LodolceAveril Ma
Jul 17, 1999·Trends in Neurosciences·B SchefflerD A Steindler
Nov 11, 1999·Parasitology Today·V McDonald
Mar 3, 2001·Current Opinion in Immunology·H R MacDonaldA Wilson
Mar 1, 2002·Current Opinion in Immunology·Delphine Guy-Grand, Pierre Vassalli
Apr 23, 2003·Trends in Microbiology·Ute HentschelMichael Steinert
May 9, 2000·Microbes and Infection·M Yamamoto, H Kiyono
Oct 29, 2002·Cytokine & Growth Factor Reviews·James P LodolceAveril Ma
Jun 6, 2003·Cytokine & Growth Factor Reviews·Alexei V TumanovSergei A Nedospasov
Apr 5, 2001·Trends in Immunology·H R MacDonaldF Radtke
Jan 20, 2010·Immunology and Cell Biology·Noorjahan Banu AlitheenPeter McCullagh
Jul 14, 1998·Nature Medicine·T W Mak, D A Ferrick
Jun 18, 2011·Nature Reviews. Immunology·Hilde CheroutreDaniel Mucida
Jan 8, 2013·Nature Reviews. Immunology·Jennifer A WalkerAndrew N J McKenzie
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·A L HartM A Kamm
Mar 19, 2002·Cellular Microbiology·Arnaud DidierlaurentMarian R Neutra
Apr 20, 1999·The Journal of Experimental Medicine·G DuludeC Perreault
May 3, 2000·The Journal of Experimental Medicine·K LakyL Puddington
Feb 21, 2002·The Journal of Experimental Medicine·Florence LambolezBenedita Rocha
Feb 5, 2003·The Journal of Experimental Medicine·Delphine Guy-GrandPierre Vassalli
Sep 19, 2007·The Journal of Experimental Medicine·Jun KunisawaHiroshi Kiyono

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.