Generation of memory B cells and plasma cells in vitro

Science
C ArpinY J Liu

Abstract

After germinal center B cells undergo somatic mutation and antigen selection, they become either memory B cells or plasma cells, but the signal requirements that control entry into either pathway have been unclear. When purified human germinal center cells were cultured with interleukin-2, interleukin-10, and cells expressing CD40 ligand, cells with characteristics of memory B cells were generated. Removal of CD40 ligand from the system resulted in terminal differentiation of germinal center B cells into cells with the characteristics of plasma cells. These results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.

References

Oct 17, 1991·Nature·J Banchereau, F Rousset
Jan 1, 1992·Immunology Today·Y J LiuI C MacLennan
Dec 21, 1989·Nature·Y J LiuI C MacLennan
Aug 1, 1994·Immunity·J XuR A Flavell
Jul 1, 1994·The Journal of Experimental Medicine·V PascualJ D Capra
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Aug 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G J ThorbeckeV K Tsiagbe
Feb 3, 1994·Nature·E A Clark, J A Ledbetter
Nov 1, 1993·The Journal of Experimental Medicine·A C FluckigerJ Banchereau
Jul 1, 1993·The Journal of Experimental Medicine·M G McHeyzer-WilliamsG J Nossal

❮ Previous
Next ❯

Citations

Oct 15, 1998·The Journal of Pathology·K Hollowood, J R Goodlad
Jan 9, 2003·European Journal of Immunology·Peter J MacardleHeddy Zola
Jun 25, 1998·Immunologic Research·M F Bachmann
Jan 15, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Sonia NéronJean-François Leblanc
Apr 2, 2009·Medizinische Klinik·Georg DultzGeorge J Kahaly
Nov 20, 2008·Cancer Immunology, Immunotherapy : CII·Tatiana M Garcia-BatesRichard P Phipps
Dec 29, 2005·Journal of Clinical Immunology·Peter DubskyA Karolina Palucka
Jun 25, 1998·In Vitro Cellular & Developmental Biology. Animal·B T PittnerE C Snow
Mar 15, 2002·Current Allergy and Asthma Reports·R L Fuleihan
Mar 9, 2004·Blood Cells, Molecules & Diseases·C Pellat-Deceunynck, R Bataille
Jan 15, 1997·Journal of Immunological Methods·A ZafiropoulosC A Borrebaeck
Jul 21, 1998·Leukemia Research·J Y BishopS M Friedman
Jul 13, 2000·Veterinary Immunology and Immunopathology·S GoedertG C Mudde
Sep 21, 2000·Immunology Letters·D Y HurW J Lee
Jan 16, 2003·Immunology Letters·Bernhard Moser, Lisa Ebert
Apr 27, 2000·Immunology Today·K AgematsuA Komiyama
Jan 1, 1997·Immunology Today·B PulendranG J Nossal
Aug 1, 1996·Current Opinion in Immunology·A B Satterthwaite, O N Witte
Jun 1, 1996·Current Opinion in Immunology·P Lane
Jun 1, 1997·Current Opinion in Immunology·C van Kooten, J Banchereau
Apr 1, 1997·Current Opinion in Immunology·Y J LiuI Fugier-Vivier
Jun 6, 2003·Cytokine & Growth Factor Reviews·Fabienne Mackay, Christine Ambrose
Nov 29, 2001·Nature Immunology·K L Calame
Sep 26, 2006·Nature Reviews. Immunology·David Tarlinton
Dec 22, 2007·Nature Reviews. Immunology·Ulf Klein, Riccardo Dalla-Favera
Mar 5, 1998·Immunology·B M SchilizziL F de Leij
Aug 14, 1999·Immunology·H TakamatsuR M Parkhouse
Aug 6, 2000·Immunology·J Gordon, J D Pound
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·María Rodríguez MartínezGustavo A Stolovitzky
Oct 28, 2006·Toxicologic Pathology·Cynthia L Willard-Mack
Nov 1, 1995·The Journal of Experimental Medicine·P GarroneJ Banchereau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.