Generation of new intercellular junctions between cardiocytes. A possible mechanism compensating for mechanical overload in the hypertrophied human adult myocardium

Circulation Research
S YamamotoK Kawamura

Abstract

Intercellular dehiscence is a common cardiocytic response to pathological conditions. However, little consideration has been given to the possibility of new intercellular junctions developing between cardiocytes within developed myocardium. To examine this possibility as it may relate to useful compensation for hemodynamic overloads, changes in cardiocytic connection were evaluated by scanning electron microscopy in hypertrophied myocardium of adult human hearts. Transmural myocardium of left ventricle was obtained at autopsy from five hearts with concentric hypertrophy, five hearts with eccentric hypertrophy, and five control hearts (noncardiac death). After formalin fixation, the number of cardiocytes connected to an individual cardiocyte was counted in tissues from the middle portion of the transmural samples by scanning electron microscopy. Cardiocytic diameter and connective tissue volume fraction were measured on the transmural sections by light microscopy. In concentrically hypertrophied hearts present both increased cardiocytic diameter and connective tissue volume fraction, the number of other cardiocytes connected to an individual cardiocyte (4.60 +/- 0.10 [mean +/- SE] was significantly increased (P < .05) compared w...Continue Reading

References

May 1, 1979·Journal of Molecular and Cellular Cardiology·R E KatholiT N James
Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Jan 1, 1976·Advances in Cardiology·A J Linzbach
Jan 1, 1991·Annual Review of Medicine·B H Lorell
May 1, 1991·The Journal of Clinical Investigation·R A Luke, J E Saffitz
May 1, 1986·Journal of the American College of Cardiology·P AnversaG Olivetti
Apr 1, 1986·The American Journal of Cardiology·D V UnverferthC V Leier
Apr 1, 1985·Journal of the American College of Cardiology·V E SmithA M Katz
Jan 1, 1985·Tissue & Cell·M S Forbes, N Sperelakis
Apr 1, 1974·Journal of Molecular and Cellular Cardiology·G E AdomianH J Swan
Jul 1, 1966·The Journal of Cell Biology·E R WeibelW F Scherle
Feb 1, 1970·The American Journal of Cardiology·N S McNutt
Jun 1, 1982·The American Journal of Anatomy·R L Moses, W C Claycomb
Jun 1, 1984·British Heart Journal·L M Shapiro, W J McKenna
Oct 1, 1980·The American Journal of Medicine·W Grossman
Mar 1, 1960·The American Journal of Cardiology·A J LINZBACH

❮ Previous
Next ❯

Citations

Jun 27, 2000·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·M OkabeY Kitaura
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·S YamamotoT N James
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·C ZuppingerH M Eppenberger
Jul 10, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Ljuba Bacharova
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Matthew J HuntSuresh C Tyagi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.