PMID: 3770042Jul 1, 1986Paper

Generation of procoagulant activity by hairy cells in response to endotoxin and phorbol esters

European Journal of Cancer & Clinical Oncology
P VieroN Semeraro

Abstract

Several investigators have suggested that hairy cells are neoplastic B lymphocytes. These cells, however, also share some biological properties with mononuclear phagocytes. A property of these cells is the capacity to generate procoagulant activity (PCA) in response to a variety of stimuli. In this study we investigated the PCA of peripheral blood hairy cells in 19 consecutive patients with hairy cell leukaemia (HCL). Monocyte-depleted blood mononuclear cells, tested immediately after isolation, expressed little, if any, activity. However, after exposure to endotoxin, a marked increase in PCA was observed (42.1 +/- 8.7 vs 1.3 +/- 0.2 units/5 X 10(1) hairy cells). A significant correlation was found between the number of lymphocytes/hairy cell and the level of endotoxin-induced PCA suggesting that lymphocytes potentiate the procoagulant response of hairy cells. When stimulated with 12-0-tetradecanoyl-phorbol-13-acetate (TPA), patients' cells produced about 2-8 times more PCA than endotoxin-stimulated cells. The PCA induced by endotoxin and TPA was identified as tissue factor. These findings suggest some further relationship between hairy cells and monocytes.

References

Feb 1, 1978·British Journal of Haematology·H M GolombD Variakojis
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Mar 1, 1975·British Journal of Haematology·H R Gralnick, C Sultan
Jan 1, 1974·British Journal of Haematology·D CatovskyD A Galton
Jan 1, 1983·Journal of Clinical Pathology·S CortellazzoN Semeraro
May 15, 1983·Thrombosis Research·H WadaS Shirakawa
Feb 1, 1983·British Journal of Haematology·T LybergK Nilsson
Oct 20, 1980·FEBS Letters·B OsterudR Seljelid

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Citations

Jan 7, 2010·American Journal of Hematology·Ioannis KotsianidisCostas Tsatalas
Apr 7, 2012·Leukemia & Lymphoma·Jan NovakTomas Kozak
May 1, 1987·European Journal of Cancer & Clinical Oncology·J Jansen

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