Generation of radical form of dipyridamole at illumination of photosynthetic reaction centers of Rb. sphaeroides

Doklady. Biochemistry and Biophysics
P P KnoxA B Rubin

Abstract

The study of the effect of vasodilator, antiplatelet agent, and inhibitor P-glycoprotein dipyridamole (DIP) on the functioning of the transmembrane protein of the reaction center (RC) of Rb. sphaeroides showed that the activation of RC by constant light generates the DIP radical cation, which significantly affects the kinetics of recombination of charges divided between photoactive bacteriochlorophyll and quinone acceptors. Thus, the antioxidant properties of DIP may affect the functional activity of membrane proteins, and this apparently should be taken into account in the studies of the mechanisms of therapeutic action of this drug.

References

May 1, 1992·Lipids·L IulianoF Violi
Jan 1, 1997·Free Radical Biology & Medicine·M F NepomucenoM Tabak
May 17, 2000·Biochimica Et Biophysica Acta·M Y OkamuraG Feher
Nov 10, 2000·Journal of Photochemistry and Photobiology. B, Biology·P P KnoxG P Borissevitc
Aug 28, 2012·Biochimica Et Biophysica Acta·Fei ZhouChang-An Yu

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