Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study.

Journal of Molecular Modeling
Fredrik HaeffnerTore Brinck

Abstract

A mechanism for the oxidation of a dimeric beta-amyloid copper ion complex is proposed based on DFT calculations. It involves the Met35 residue, which is believed to be important in the neurotoxicity causing Alzheimer's disease. Oxidation of Met35 is found to proceed readily with dioxygen when two Met35 residues are close to each other and the copper ion. This indicates that oxidants, such as hydrogen peroxide, are not necessary for oxidation of beta-amyloid copper ion complexes. Understanding these processes could be pivotal in gaining more knowledge of this complex disease and for the development of therapeutic treatments.

References

Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Jan 22, 2004·Journal of the American Chemical Society·Jhih-Wei Chu, Bernhardt L Trout
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Roy G CutlerMark P Mattson
Jul 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin J BarnhamAshley I Bush
Aug 6, 2004·Nature·Mark P Mattson
Feb 1, 2005·Biochimica Et Biophysica Acta·D Allan Butterfield, Debra Boyd-Kimball
Aug 23, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Luc GuilloreauPeter Faller
Jul 5, 2008·Biophysical Journal·Victor A StreltsovJoseph N Varghese
Jan 6, 2009·Journal of the American Chemical Society·Simon C DrewKevin J Barnham

❮ Previous
Next ❯

Citations

Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Colin L Masters, Dennis J Selkoe
Dec 5, 2015·The Journal of Physical Chemistry. a·Nicolas P A MonneyRichard S Glass
Aug 27, 2011·Metallomics : Integrated Biometal Science·Leonid Breydo, Vladimir N Uversky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.