Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmitters

Pharmacological Reviews
V Simonneaux, C Ribelayga

Abstract

Melatonin, the major hormone produced by the pineal gland, displays characteristic daily and seasonal patterns of secretion. These robust and predictable rhythms in circulating melatonin are strong synchronizers for the expression of numerous physiological processes in photoperiodic species. In mammals, the nighttime production of melatonin is mainly driven by the circadian clock, situated in the suprachiasmatic nucleus of the hypothalamus, which controls the release of norepinephrine from the dense pineal sympathetic afferents. The pivotal role of norepinephrine in the nocturnal stimulation of melatonin synthesis has been extensively dissected at the cellular and molecular levels. Besides the noradrenergic input, the presence of numerous other transmitters originating from various sources has been reported in the pineal gland. Many of these are neuropeptides and appear to contribute to the regulation of melatonin synthesis by modulating the effects of norepinephrine on pineal biochemistry. The aim of this review is firstly to update our knowledge of the cellular and molecular events underlying the noradrenergic control of melatonin synthesis; and secondly to gather together early and recent data on the effects of the nonadrene...Continue Reading

References

Sep 11, 1978·Biochimica Et Biophysica Acta·G L BrammerL Wetterberg
Mar 1, 1975·The American Journal of Anatomy·G PelletierA V Schally
Mar 29, 1975·Lancet·R J ReiterL Y Johnson
Aug 1, 1978·The Journal of Comparative Neurology·R Y MooreB E Jones
Feb 1, 1979·Endocrinology·S M ReppertD C Klein
Jun 1, 1979·Pediatric Research·S M ReppertD C Klein
Oct 1, 1978·Journal of Neurochemistry·B R Sitaram, G J Lees
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·K E WintersW Lovenberg
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y OzakiH J Lynch
Apr 15, 1977·Life Sciences·J P Preslock
Jan 31, 1978·Cell and Tissue Research·R M BuijsF W van Leeuwen
Dec 16, 1977·Brain Research·H ShibuyaS Watanabe
Feb 18, 1977·Science·L HedlundG D Niswender
Jan 1, 1976·Brain Research Bulletin·A J KastinA V Schally
Oct 21, 1976·Journal of Theoretical Biology·G Burnstock
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianJ Axelrod
Feb 1, 1975·Endocrinology·I HaulicaL Ionescu
Jan 1, 1976·The Journal of Clinical Endocrinology and Metabolism·L WetterbergT Heyden

❮ Previous
Next ❯

Citations

Sep 9, 2004·Journal of Physiology and Biochemistry·J BarrenetxeJ A Martínez
Aug 30, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anna Lorenc-DudaJolanta B Zawilska
Aug 10, 2006·Cell and Tissue Research·Lutz Hein
Mar 24, 2007·Reviews in Endocrine & Metabolic Disorders·Florent G RevelValérie Simonneaux
Dec 22, 2009·Reviews in Endocrine & Metabolic Disorders·Asamanja ChattorajJimo Borjigin
Sep 28, 2012·Current Diabetes Reports·Cecilia Nagorny, Valeriya Lyssenko
Jun 29, 2012·Neurotoxicity Research·Seithikurippu R Pandi-PerumalDaniel P Cardinali
Jan 27, 2004·Brain Research. Molecular Brain Research·V SimonneauxP Pévet
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·K Plaut, T Casey
May 17, 2007·Molecular Psychiatry·J MelkeT Bourgeron
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·T Bourgeron
Aug 18, 2012·International Journal of Dentistry·V K Chava, K Sirisha
Apr 29, 2011·Neuroendocrinology·Prapimpun WongchitratValérie Simonneaux
Aug 4, 2011·Neuropsychobiology·Gerald PailSiegfried Kasper
Jul 23, 2011·Neuroendocrinology·Sandrine M Dupré
Oct 24, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mean-Hwan KimDuk-Su Koh
Jun 2, 2007·Journal of Periodontology·Antonio CutandoRussel J Reiter
Oct 17, 2013·International Journal of Molecular Sciences·Sylvie TordjmanJulie Vernay-Leconte
Feb 27, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Maria Elena MancaFiammetta Berlinguer
Oct 19, 2013·Tropical Animal Health and Production·Larissa ZetouniHumberto Tonhati
Dec 3, 2014·Journal of Photochemistry and Photobiology. B, Biology·Soumik Goswami, Chandana Haldar
Aug 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wootae KimJa-Eun Kim
Mar 3, 2015·Expert Opinion on Therapeutic Targets·Frank BellivierJan Scott
Nov 3, 2011·Stress : the International Journal on the Biology of Stress·Z S FerreiraV Simonneaux
Sep 10, 2008·Chronobiology International·Khalid El AllaliValérie Simonneaux
May 12, 2006·Chronobiology International·Florent G RevelValérie Simonneaux
Nov 15, 2011·Chronobiology International·Konrad SchöttnerDietmar Weinert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.