Generation of thrombin in blood plasma of non-pregnant and pregnant women studied through concentration of thrombin-antithrombin III complexes

European Journal of Obstetrics, Gynecology, and Reproductive Biology
M Uszyński

Abstract

The main question in this study is how much more thrombin is generated in blood plasma of pregnant women than in non-pregnant women. Thrombin-antithrombin III complexes (TAT) were used as markers of thrombin generation in vivo. They were measured by the ELISA method in blood plasma of 15 non-pregnant and 43 pregnant, as well as 30 parturient women and 10 women after delivery. With normal menstrual cycles, TAT levels did not change significantly throughout the cyclic phases, and the mean +/- S.D. calculated for all cyclic phases was 1.9 +/- 0.3 micrograms/l. In the 2nd trimester the level of TAT was 16.0 +/- 2.8 micrograms/l and at term 21.5 +/- 11.9 micrograms/l. Throughout the 1st and 2nd stage of labour the level of TAT increased insignificantly, but after placenta separation it was significantly higher than before labour (30.8 +/- 20.4 micrograms/l). In the 3rd and 7th days after delivery the level of TAT was still higher than in non-pregnant women. It was found that the level of TAT in normal menstrual cycles is stable, whereas it increases in pregnancy. Relating the values of the cycle to those of pregnancy it was calculated, that at the end of pregnancy there is a ten-fold increase of TAT level and after placenta separati...Continue Reading

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Citations

Nov 14, 2002·The Journal of Obstetrics and Gynaecology Research·Yasuhiko EbinaSeiichiro Fujimoto
Apr 21, 2012·Gynecologic and Obstetric Investigation·A ChuiJ M Said
May 27, 2008·Thrombosis Research·R Rafik HamadK Bremme
Feb 1, 2006·The Journal of Obstetrics and Gynaecology Research·Takashi WatanabeMitsuaki Suzuki
Dec 2, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·David N HackneyHyagriv N Simhan
Jun 1, 2010·American Journal of Obstetrics and Gynecology·David N HackneyHyagriv N Simhan
Nov 22, 2001·American Journal of Obstetrics and Gynecology·M A ElovitzM Phillippe
Mar 3, 2001·American Journal of Obstetrics and Gynecology·T BombeliJ Fehr
Dec 6, 2011·The American Journal of Pathology·Amy ChuiJoanne M Said
Apr 26, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezSonia S Hassan
Aug 4, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicSonia S Hassan
Jun 24, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezChong Jai Kim
Sep 9, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezRoberto Romero
Aug 7, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·David N HackneyHyagriv N Simhan
Nov 11, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezMoshe Mazor

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