Generation of VV-hemorphin-7 from globin by peritoneal macrophages

FEBS Letters
N DagouassatJ M Piot

Abstract

Bovine globin has been incubated with mice peritoneal macrophages in order to study its hydrolysis by lysosomal enzymes, among which chiefly cathepsin D. Analysis of resulting peptides, by reversed-phase high-performance liquid chromatography (RP-HPLC), showed the release of a bioactive peptide, VV-hemorphin-7. When a carboxyl proteinase inhibitor such as pepstatin A was added, no hemorphin was generated. Our results clearly demonstrated that VV-hemorphin-7 generation was principally due to cathepsin D. This study allowed us to hypothesize a possible pathway for in vivo hemorphins appearance from globin catabolism by macrophages.

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Citations

Jan 1, 1997·Biopolymers·Q ZhaoJ M Piot
Oct 22, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marie CohenJean-Marie Piot
Aug 6, 2013·Peptides·Natalia M RibeiroCamila S Dale
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·E V Navolotskaya
Mar 10, 2001·Biochemical and Biophysical Research Communications·J SzikraA Borsodi
Jul 3, 2002·Bioscience, Biotechnology, and Biochemistry·Yunden Jinsmaa, Masaaki Yoshikawa
Dec 8, 2009·Neurochemical Research·Nina BarkhudaryanFriedrich Lottspeich
Jan 18, 2005·Peptides·Camila Squarzoni DaleEmer Suavinho Ferro
Jul 8, 1998·FEBS Letters·O N YatskinV T Ivanov
Jun 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thalie DevosseMarc Parmentier
Dec 26, 2002·The Journal of Biological Chemistry·Vanessa RioliEmer S Ferro
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T S LiangP M Murphy
Oct 16, 2019·Scientific Reports·Amanat AliRanjit Vijayan
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Przemyslaw MielczarekJerzy Silberring
Nov 14, 2006·Peptides·Laurence MurilloIngrid Fruitier-Arnaudin

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