Generational differences in the age at diagnosis with Ibd: genetic anticipation, bias, or temporal effects

The American Journal of Gastroenterology
E M FaybushC N Bernstein

Abstract

Previous cross-sectional research has demonstrated generational differences in age at diagnosis (AAD) in inflammatory bowel disease (IBD). This observation has at times been ascribed to genetic anticipation, but could also be due to biases related to case ascertainment or follow-up or to temporal changes in IBD epidemiology. We aimed to explore this issue using a population-based database. In 1995 we used the comprehensive administrative databases in the province of Manitoba, Canada to establish a population-based IBD Research Registry that includes clinical and demographic information for persons. We contacted those subjects within our Research Registry who reported having any family members with IBD and their family members for verification of diagnosis and AAD. Differences in AAD between familial pairs were calculated. In addition, to assess whether duration of follow-up accounted for generational differences in AAD, we computed the mean AAD for subjects with and without family histories of IBD based on age at the time of interview (i.e., < 45 and > or = 45 yr of age). Of the 2445 persons with IBD in the Research Registry, 548 reported positive family histories, and 315 of these (58%) were reached by telephone. There were 16...Continue Reading

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Citations

Jun 24, 2005·Gut·C D McFaulUNKNOWN German National Case Collection for Familial Pancreatic Cancer (FaPaCa)
Mar 7, 2007·The American Journal of Gastroenterology·Marian C AldhousJack Satsangi
Mar 7, 2007·The American Journal of Gastroenterology·Marian C AldhousJack Satsangi
May 13, 2009·Inflammatory Bowel Diseases·May-Bente BengtsonUNKNOWN Ibsen Study Group
Apr 2, 2002·The American Journal of Gastroenterology·Michael F Picco
Mar 25, 2015·The American Journal of Gastroenterology·Frederik Trier MollerTine Jess
Jul 31, 2007·Alimentary Pharmacology & Therapeutics·Z S HeetunC O'Morain
Nov 2, 2019·Journal of Gastroenterology and Hepatology·Sang Hyoung ParkSuk-Kyun Yang
Jan 7, 2014·Journal of Crohn's & Colitis·Eduard CabréUNKNOWN ENEIDA Project of the Spanish Working Group in Crohn's Disease and Ulcerative Colitis (GETECCU)
Sep 5, 2018·Digestive Diseases and Sciences·Elena R SchiffAdam P Levine
Feb 21, 2019·Canine Genetics and Epidemiology·Dan G O'NeillAlex G Gough
Sep 22, 2020·World Journal of Gastrointestinal Pharmacology and Therapeutics·Brindusa TrutaSteven R Brant
Jun 15, 2006·World Journal of Gastroenterology : WJG·Leena HalmeKimmo Kontula
May 26, 2004·Best Practice & Research. Clinical Gastroenterology·R K Russell, J Satsangi

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