Generic rules of mechano-regulation combined with subject specific loading conditions can explain bone adaptation after THA.

PloS One
Tomasz D SzwedowskiGeorg N Duda

Abstract

Bone adaptation after total hip arthroplasty is associated with the change in internal load environment, and can result in compromised bone stock, which presents a considerable challenge should a revision procedure be required. Under the assumption of a generic mechano-regulatory algorithm for governing bone adaptation, the aim of this study was to understand the contribution of subject specific loading conditions towards explaining the local periprosthetic remodelling variations in patients. CT scans of 3 consecutive THA patients were obtained and used for the construction of subject specific finite element models using verified musculoskeletal loading and physiological boundary conditions. Using either strain energy density or equivalent strain as mechano-transduction signals, predictions of bone adaptation were compared to DEXA derived BMD changes from 7 days to 12 months post-implantation. Individual changes in BMD of up to 33.6% were observed within the 12 month follow-up period, together with considerable inter-patient variability of up to 26%. Estimates of bone adaptation using equivalent strain and balanced loading conditions led to the best agreement with in vivo measured BMD, with RMS errors of only 3.9%, 7.3% and 7.3...Continue Reading

References

Nov 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B J KiratliM A Wilson
Jan 1, 1987·Journal of Biomechanics·R HuiskesT J Slooff
Dec 1, 1987·Acta Orthopaedica Scandinavica·R Huiskes
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C T Rubin, L E Lanyon
Sep 1, 1987·The Anatomical Record·H M Frost
Mar 1, 1971·The American Journal of Medicine·B FrameG Fine
Apr 1, 1995·Journal of Biomechanics·B Mikić, D R Carter
Nov 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C M LesA J Kaneps
Jul 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H WeinansJ O Galante
Sep 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J M BryanJ O Galante
Jan 1, 1997·The Journal of Bone and Joint Surgery. British Volume·G H Van LentheR Huiskes
Dec 10, 1997·Journal of Biomechanics·M A StülpnerA Spirakis
Nov 5, 1998·Journal of Biomechanics·G N DudaL Claes
Jun 19, 2001·Journal of Biomechanics·G BergmannG N Duda
Jun 19, 2001·Journal of Biomechanics·M O HellerG N Duda
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J Mark WilkinsonRichard Eastell
Aug 16, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ralf U KleemannGeorg N Duda
Sep 19, 2003·Langenbeck's Archives of Surgery·Markus O HellerGeorg N Duda
Oct 16, 2003·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·W R TaylorS E Clift
Nov 13, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Harold M Frost
Apr 22, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·William R TaylorGeorg N Duda
Oct 30, 2004·Computer Methods in Biomechanics and Biomedical Engineering·W R TaylorS E Clift
Nov 3, 2004·Journal of Biomechanics·Charalampos BitsakosAndrew A Amis
Jan 15, 2005·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·M J SchmitzH Bereiter
Mar 2, 2005·Clinical Orthopaedics and Related Research·Carsten PerkaGeorg N Duda
Mar 31, 2005·Journal of Biomechanics·M O HellerG N Duda
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A W L TurnerW R Walsh
Mar 4, 2006·Clinical Biomechanics·Devakara R EpariGeorg N Duda
May 25, 2006·Clinical Orthopaedics and Related Research·Teri G RosenbaumD Kevin Lester
Dec 15, 2006·Journal of Biomechanics·Andrew D SpeirsWilliam R Taylor
Dec 8, 2009·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Dagmar KainmuellerHans-Christian Hege
Feb 11, 2010·Clinical Orthopaedics and Related Research·Julius Wolff
Feb 18, 2010·Clinical Orthopaedics and Related Research·Julius Wolff

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Citations

May 3, 2014·PloS One·Antonia TorcasioG Harry van Lenthe
Jan 3, 2013·International Journal for Numerical Methods in Biomedical Engineering·Pankaj Pankaj
Apr 29, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Mariska WesselingIlse Jonkers
Feb 9, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Myriam CillaGeorg N Duda
Dec 4, 2020·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Massimo FranceschiniTomaso Villa
Jan 13, 2015·Journal of Biomechanics·D R Sumner

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Methods Mentioned

BETA
total hip arthroplasty

Software Mentioned

MSC
Abaqus
MSC Patran
Geomagic
Geomagic Studio
Mindways

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