Generic switching and non-persistence among medicine users: a combined population-based questionnaire and register study

PloS One
Jette RatheJens Søndergaard

Abstract

Generic substitution means that one medicinal product is replaced by another product containing the same active substance. It is strictly regulated with respect to its bioequivalence, and all products must have undergone appropriate studies. Although generic substitution is widely implemented, it still remains to be answered how generic switch influences persistence to long-term treatment, and if it is modified by patients' concerns about medicine and views on generic medicine. This study focuses on users of antidepressants and antiepileptics, and their experience of generic switching. The study was an observational cohort study. By use of a prescription database, we identified patients who had redeemed prescriptions on generically substitutable drugs, and a questionnaire was mailed to them. We analyzed predictors of discontinuation in relation to generic switch and patients' attitudes towards generic medicines and concerns about their medicine. Patients who experience their first-time switch of a specific drug were at higher risk of non-persistence, Hazard Ratio 2.98, 95% CI (1.81;4.89) versus those who have never switched, and 35.7% became non-persistent during the first year of follow-up. Generic switching did not influence ...Continue Reading

References

Oct 27, 2001·Journal of Clinical Pharmacy and Therapeutics·E VermeireJ Denekens
Apr 23, 2002·British Journal of Clinical Pharmacology·John LarsenLars F Gram
Dec 21, 2004·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·K Møller Pedersen
Nov 24, 2005·The Annals of Pharmacotherapy·Boris L G Van WijkAnthonius de Boer
Dec 20, 2005·Journal of Clinical Epidemiology·Boris L G Van WijkAnthonius de Boer
Mar 4, 2006·Pharmacoepidemiology and Drug Safety·Susan E AndradeK Arnold Chan
Jan 31, 2007·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew M PetersonMichael Nichol
Jul 4, 2007·Primary Care Companion to the Journal of Clinical Psychiatry·Vivien M HunotRachel C Churchill
Oct 5, 2007·Patient Education and Counseling·Ann-Charlotte MårdbyTove Jörgensen
Jul 1, 2008·Epilepsy & Behavior : E&B·Michel J BergKenneth J Tomaszewski
Jan 8, 2009·The Annals of Pharmacotherapy·Bradley C MartinBetsy Lynn Sleath
Mar 10, 2010·Journal of Psychosocial Nursing and Mental Health Services·Robert H Howland
Jun 22, 2010·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·T Ian BarronJohn Feely
Nov 26, 2010·Expert Review of Neurotherapeutics·Josemir W SanderJürgen Bauer
Mar 26, 2011·The American Journal of Medicine·William H ShrankNiteesh K Choudhry
Apr 14, 2011·British Journal of Clinical Pharmacology·Atholl JohnstonJosé Zamorano
Apr 29, 2011·BMC Health Services Research·Petros PechlivanoglouMaarten J Postma
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
Oct 13, 2011·British Journal of Clinical Pharmacology·John B Warren, Kersti Oselin
Nov 23, 2011·Pediatrics·Susan E AndradeJerry H Gurwitz
Nov 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O Ström, E Landfeldt
May 12, 2012·European Journal of Clinical Pharmacology·Kamilla ØstergaardDavid Gaist
Oct 2, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Johannes HamannStefan Leucht
Nov 15, 2012·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Roger K Verbeeck, Flora T Musuamba
Jan 2, 2013·JAMA Internal Medicine·Aaron S KesselheimNiteesh K Choudhry
Feb 14, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Pieter DylstSteven Simoens
Jun 15, 2013·European Journal of Clinical Pharmacology·Jette RatheJens Soendergaard
Sep 17, 2013·Pharmacoepidemiology and Drug Safety·Charlotte OlesenElse Marie Damsgaard
Apr 2, 2014·International Journal of Family Medicine·Abdullah Alhewiti

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Citations

Sep 29, 2015·Annals of General Psychiatry·Slawomir MurawiecPrzemyslaw Bienkowski
Apr 4, 2017·Pharmacoepidemiology and Drug Safety·Aaron S KesselheimEric G Campbell
Sep 12, 2018·European Journal of Public Health·Rafael B GoldszmidtMarco A Bianchini

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