Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration.

Proceedings of the National Academy of Sciences of the United States of America
Tetsuhiro S Hatakeyama, Kunihiko Kaneko

Abstract

Circadian clocks--ubiquitous in life forms ranging from bacteria to multicellular organisms--often exhibit intrinsic temperature compensation; the period of circadian oscillators is maintained constant over a range of physiological temperatures, despite the expected Arrhenius form for the reaction coefficient. Observations have shown that the amplitude of the oscillation depends on the temperature but the period does not; this suggests that although not every reaction step is temperature independent, the total system comprising several reactions still exhibits compensation. Here we present a general mechanism for such temperature compensation. Consider a system with multiple activation energy barriers for reactions, with a common enzyme shared across several reaction steps. The steps with the highest activation energy rate-limit the cycle when the temperature is not high. If the total abundance of the enzyme is limited, the amount of free enzyme available to catalyze a specific reaction decreases as more substrates bind to the common enzyme. We show that this change in free enzyme abundance compensates for the Arrhenius-type temperature dependence of the reaction coefficient. Taking the example of circadian clocks with cyanobac...Continue Reading

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Citations

Oct 23, 2012·Cell Reports·Craig C JolleyHiroki R Ueda
Jan 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Faiza HussainMatthew R Bennett
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