Genes and environment in multiple sclerosis: Impact of temporal changes in the sex ratio on recurrence risks.

Multiple Sclerosis : Clinical and Laboratory Research
A D SadovnickGabriele C DeLuca

Abstract

To evaluate the impact of temporal increase of female to male (F:M) sex ratio for persons with multiple sclerosis (MS) on the familial risk (empiric recurrence risks or RRs) for biological relatives of affected individuals. Detailed family histories were systematically obtained from people with MS attending the University of British Columbia Hospital MS Clinic. The study cohort was born in 1970 or more recently. Data were collected from 1 September 2015 to 31 January 2019. The study was designed to allow only one proband per family. Age-corrected RRs for biological relatives of probands were calculated based on a modification of the maximum-likelihood approach. Data analyses were possible for 746 unique probands (531 females; 215 males) and 19,585 of their biological relatives. RRs were temporally impacted. Both genetic sharing and environmental factors are important in determining RRs. It appears that there is an increase in MS risk due to environmental factors in later life (i.e. not shared family environment). Environmental exposures in genetically predisposed individuals might be driving the MS risk. The increase in F:M ratio of RRs for sisters/brothers of female probands over time is likely due to environmental differences.

References

Mar 1, 1988·American Journal of Medical Genetics·A D SadovnickR H Ward
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen M Spach, Colleen E Hayes
Oct 21, 2006·Lancet Neurology·Sarah-Michelle OrtonUNKNOWN Canadian Collaborative Study Group
Nov 11, 2009·Current Opinion in Gastroenterology·Ruth E Ley
Jan 8, 2013·Journal of Neurology·Margitta T KampmanOivind Torkildsen
Sep 28, 2013·Canadian Journal of Diabetes·Ian Janssen
Jul 10, 2014·The Journal of Endocrinology·Milos Mraz, Martin Haluzik
Aug 6, 2014·Autoimmunity Reviews·Mathilde VersiniYehuda Shoenfeld
Nov 22, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Wallace J BrownleeDavid H Miller
Jan 13, 2015·Journal of the Royal Society of Medicine·Austin Bradford Hill
Jan 15, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Corrado FagnaniGiovanni Ristori
Jun 6, 2015·Acta Neurologica Scandinavica·I Boström, A-M Landtblom
Jul 18, 2015·Neurology. Neuroimmunology and Neuroinflammation·Federica EspositoFilippo Martinelli Boneschi
Oct 16, 2015·Multiple Sclerosis : Clinical and Laboratory Research·A K HedströmL Alfredsson
Dec 19, 2016·Journal of Neurology & Neuromedicine·Milena A Gianfrancesco, Lisa F Barcellos
May 4, 2017·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mahdi Bijanzadeh
Oct 23, 2017·Multiple Sclerosis and Related Disorders·Michelle L Degelman, Katya M Herman
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Oct 23, 2018·Cell·UNKNOWN International Multiple Sclerosis Genetics Consortium. Electronic address: chris.cotsapas@yale.edu, UNKNOWN International Multiple Sclerosis Genetics Consortium
Dec 24, 2018·Journal of Neurology·Jie SongAli Manouchehrinia
Oct 12, 2019·Science·UNKNOWN International Multiple Sclerosis Genetics Consortium
Oct 12, 2019·Science·Farren Briggs
Dec 17, 2019·JAMA Neurology·Mattia Rosso, Tanuja Chitnis
Dec 22, 2019·Trends in Molecular Medicine·Amit Bar-OrManher A Joshi
Mar 24, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Benjamin M JacobsRuth Dobson
Feb 12, 2021·Multiple Sclerosis and Related Disorders·Amirreza NaseriMahnaz Talebi

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