Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative

Biogerontology
Jennifer Nicola M ReaI M Rea

Abstract

Understanding how to 'Age Longer and Age Well' is a priority for people personally, for populations globally and for government policy. Nonagenarians are the oldest members of our societies and survivors of their generation. Approximately 10 % of nonagenarians reach 90 years and beyond in good condition and seem to have a combination of both age-span and health-span. But what are the factors which help people reach their ninetieth birthday and beyond in good condition? Are they genetics, as in 'nature', or do they depend on 'nurture' and are related to environment, or are both factors inextricably intertwined within the concept of behavioural genetics? Nonagenarians have rich life experiences that can teach us much about ageing well; they are reservoirs of genetic, life-style and behavioural information which can help dissect out how to live not only longer but better. Personal family history and narrative are powerful tools that help to determine familial traits, beliefs and social behaviours and when used in parallel with new biotechnology methods inform and elaborate causality. Here we present themes and insights from personal narrative enquiry from nonagenarian participants from the Belfast Elderly Longitudinal Free-living ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 1, 1984·Mechanisms of Ageing and Development·G J LigthartG G Steinmann
Jan 12, 1995·Nature·S A NeeperC Cotman
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Jan 1, 1994·Atherosclerosis·K KervinenY A Kesäniemi
Feb 1, 1993·Journal of the American Geriatrics Society·W B Ershler
Jan 1, 1993·Genetic Epidemiology·J A CauleyL H Kuller
Aug 1, 1997·The Gerontologist·J W Rowe, R L Kahn
Nov 5, 1997·Journal of Clinical Immunology·C MiyajiT Abo
Feb 25, 1998·Journal of Clinical Immunology·S E McNerlanT C Morris
Oct 29, 1998·Mechanisms of Ageing and Development·Z Jian-GangH Lin
Feb 22, 2000·Annals of the New York Academy of Sciences·D D FrancisM J Meaney
Mar 30, 2000·Annals of Human Genetics·R M Corbo, R Scacchi
Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Dec 20, 2000·Physiological Genomics·J M HagbergR E Ferrell
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G B FrisoniM Trabucchi
Jul 27, 2001·Mechanisms of Ageing and Development·I M ReaUNKNOWN MONICA group (Belfast). Monitoring of Cardiovascular trends study group
Mar 8, 2002·American Journal of Epidemiology·June E EichnerBerrit C Stroehla
Apr 27, 2002·Annals of the New York Academy of Sciences·Thomas Perls
Oct 3, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D LioC Caruso
Feb 21, 2003·Annals of the Rheumatic Diseases·L SköldstamG Johansson
Mar 14, 2003·Mechanisms of Ageing and Development·Owen A RossI Maeve Rea
Mar 14, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jessica EvertThomas Perls
Apr 30, 2003·The American Journal of Clinical Nutrition·Lindsey F MassonAlison Avenell
Jul 23, 2004·Aging Cell·Eugenio Mocchegiani, Marco Malavolta
Aug 4, 2004·Experimental Gerontology·Lynn D MaxwellDerek Middleton
Jan 18, 2006·Brain Research·Shoshanna S VaynmanFernando Gomez-Pinilla
Mar 4, 2006·Public Health Nutrition·Michel de Lorgeril, Patricia Salen
Aug 2, 2006·Journal of Psychosomatic Research·Jean-Paul GlaserInez Myin-Germeys
Sep 18, 2007·Ageing Research Reviews·Zsolt RadakSataro Goto
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Anna M BennetJohn Danesh
Nov 8, 2007·Annals of the New York Academy of Sciences·S Jay OlshanskyRobert N Butler
Feb 13, 2008·Archives of Internal Medicine·Laurel B YatesJ Michael Gaziano
Mar 28, 2008·Journal of Epidemiology and Community Health·F ZhangJ Liu
Sep 11, 2008·Developmental Neurorehabilitation·Michelle Ploughman
Oct 22, 2008·Ageing Research Reviews·Danilo Di BonaCalogero Caruso
Oct 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bastiaan T HeijmansL H Lumey

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Citations

Jul 3, 2015·Biogerontology·Irene Maeve ReaUNKNOWN ACUME2 Project
Aug 5, 2015·Biogerontology·Guillermo López-Lluch, Suresh I S Rattan
Apr 25, 2018·Frontiers in Immunology·Irene Maeve ReaOwen A Ross
Dec 11, 2020·ELife·Hillary A MillerScott F Leiser

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