Genes and the parsing of cognitive processes

Trends in Cognitive Sciences
Terry E Goldberg, Daniel R Weinberger

Abstract

Now that the human genome has been sequenced there exists the possibility of identifying specific genes that affect human cognition. In this article, recent studies that have found associations between common gene variants and specific cognitive processes are reviewed. Several principles for evaluating this new field are also discussed. The interpretation of results is far from simple because a single gene can affect multiple processes, multiple genes can impact on a single process, and multiple cognitive processes are intercorrelated. In general, functional neuroimaging has been a more sensitive assay of cognitive processing than behavioral measures used alone, although there are important caveats regarding its use. Replicated findings so far involve associations between a COMT polymorphism and prefrontally-based executive functions and neurophysiology, and a BDNF polymorphism and medial-temporal-cortex based declarative memory processes. Implicit in this review is a concern that many of the cognitive paradigms used evolved for purposes well outside those described here. As such it may be necessary to view cognition in novel ways, based on constraints imposed by genomics and neurobiology, in order to increase the effect size o...Continue Reading

References

Aug 17, 1995·Nature·G V Williams, P S Goldman-Rakic
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
May 20, 1999·Annual Review of Pharmacology and Toxicology·R M WeinshilboumC L Szumlanski
May 17, 2000·American Journal of Medical Genetics·R FreedmanS Leonard
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Apr 2, 2002·The American Journal of Psychiatry·Anil K MalhotraDavid Goldman
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert P Carson, David Robertson
Jun 6, 2002·American Journal of Human Genetics·Christopher W BartlettLinda M Brzustowicz
Aug 23, 2002·Molecular Psychiatry·A N KlugerR P Ebstein
Oct 3, 2002·Nature Reviews. Neuroscience·Simon E Fisher, John C DeFries
Nov 28, 2002·Psychiatric Genetics·Brion S MaherMichael M Vanyukov
Dec 18, 2002·Journal of Neurobiology·Thomas J Bouchard, Matt McGue
Feb 1, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Agatino Battaglia, John C Carey
Feb 1, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jie Xu, Zhong Chen
Feb 15, 2003·American Journal of Human Genetics·Angela J MarlowLon R Cardon
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 17, 2003·British Medical Bulletin·Ahmad R Hariri, Daniel R Weinberger
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
May 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jin FanMichael I Posner
Jul 10, 2003·Lancet Neurology·Clyde FrancksAnthony P Monaco
Jul 23, 2003·Journal of the American Academy of Child and Adolescent Psychiatry·Sandra K LooMartin L Reite
Jan 2, 2004·The American Journal of Psychiatry·Adele DiamondLorrie Gehlbach

❮ Previous
Next ❯

Citations

Sep 13, 2014·Current Behavioral Neuroscience Reports·Alexandra D ForrestSteven J Siegel
Aug 1, 2014·Brain : a Journal of Neurology·Cristina NombelaRoger A Barker
Sep 14, 2013·Trends in Cognitive Sciences·Michelle W VossHenriette van Praag
Feb 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Giuseppe Blasi, Alessandro Bertolino
Nov 15, 2006·Schizophrenia Bulletin·Raquel E GurWilliam S Stone
Dec 14, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jiansong XuEdythe D London
Dec 11, 2008·PLoS Biology·John A ClitheroScott A Huettel
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·P M GreenwoodR Parasuraman
Jun 27, 2009·BMC Neuroscience·Cyril R PernetGuillaume A Rousselet
Jan 20, 2010·Social Cognitive and Affective Neuroscience·Elizabeth A Reynolds LosinMarco Iacoboni
Jan 11, 2013·Journal of Aging Research·Regina L LeckieKirk I Erickson
Aug 16, 2005·Current Psychiatry Reports·Thomas W Weickert, Terry E Goldberg
Sep 21, 2007·Current Psychiatry Reports·Mitsuru Toda, Anissa Abi-Dargham
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bernice PorjeszHenri Begleiter
Dec 31, 2008·The Journal of the American Academy of Psychoanalysis and Dynamic Psychiatry·Jane G Tillman
Nov 10, 2009·Der Nervenarzt·F Poustka, W Maier
Aug 19, 2007·Neuropsychology Review·J Cobb ScottIgor Grant
Jul 30, 2009·Neuropsychology Review·Victoria M Leavitt, Terry E Goldberg
Jan 25, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Theresa M BeckerCameron S Carter
Dec 1, 2012·Psychological Medicine·G DonohoeK E Burdick
Nov 3, 2005·Development and Psychopathology·Dante Cicchetti, Michael I Posner
Nov 30, 2010·Journal of Clinical and Experimental Neuropsychology·Laura A RabinKatherine E Nutter-Upham
May 25, 2006·European Journal of Human Genetics : EJHG·Ian J DearyTimothy C Bates
Feb 28, 2008·Molecular Psychiatry·H Le-NiculescuA B Niculescu
Dec 13, 2005·Behavior Genetics·Steven BuyskePaul Manowitz
Mar 1, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Makio Kashino, Hirohito M Kondo
Jul 28, 2009·Cognitive Neuropsychiatry·Brita Elvevåg, Daniel R Weinberger
Jul 28, 2009·Cognitive Neuropsychiatry·Abraham ReichenbergJames H MacCabe
Sep 8, 2005·Developmental Neuropsychology·M Rosario RuedaMary K Rothbart
Dec 26, 2012·Perceptual and Motor Skills·Akiko KinoshitaShigeto Yamawaki
Jun 29, 2014·Epilepsy & Behavior : E&B·Robyn M BuschCharis Eng
Nov 5, 2013·Seminars in Oncology Nursing·John D MerrimanBradley E Aouizerat

❮ Previous
Next ❯

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