Genes and the preeclampsia syndrome

Journal of Perinatal Medicine
Sabine MützeWerner Rath

Abstract

Preeclampsia is specific to pregnancy and is still a leading cause of maternal and perinatal mortality and morbidity, affecting about 3% of women, but the underlying pathogenetic mechanisms still remain unclear. Immune maladaptation, placental ischemia and increased oxidative stress represent the main components discussed to be of etiologic importance, and they all may have genetic implications. Since the familial nature of preeclampsia is known for many years, extensive research on the genetic contribution to the pathogenesis of this severe pregnancy disorder has been performed. In this review, we will overview the linkage and candidate gene studies carried out so far as well as summarize important historical notes on the genetic hypotheses generated in preeclampsia research. Moreover, the influence of maternal and fetal genes and their interaction as well as the role of genomic imprinting in preeclampsia will be discussed.

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Nov 16, 1991·BMJ : British Medical Journal·J G Thornton, J L Onwude
Nov 1, 1991·American Journal of Obstetrics and Gynecology·B M SibaiC Sarinoglu
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·R ArngrimssonG Snaedal
Feb 1, 1985·British Journal of Obstetrics and Gynaecology·D M CampbellR Carr-Hill
Aug 1, 1981·British Journal of Obstetrics and Gynaecology·A SutherlandI MacGillivray
Oct 1, 1995·American Journal of Obstetrics and Gynecology·G A DekkerH P van Geijn
Jun 1, 1995·British Journal of Obstetrics and Gynaecology·L MorganN Kalsheker
Jan 1, 1994·Acta Obstetricia Et Gynecologica Scandinavica·R ArngrímssonJ J Walker
Dec 1, 1993·The Quarterly Review of Biology·D Haig
Apr 1, 1996·Clinical and Experimental Immunology·G ChenJ H McKillop
Oct 1, 1996·American Journal of Obstetrics and Gynecology·D S Dizon-TownsonK Ward
Jun 1, 1997·Journal of Medical Genetics·S SohdaT Kubo
Aug 1, 1997·American Journal of Human Genetics·R ArngrímssonF Soubrier
Mar 20, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R B Cincotta, S P Brennecke
Apr 16, 1998·American Journal of Obstetrics and Gynecology·T TyniH Pihko
Jun 6, 1998·BMJ : British Medical Journal·R T LieL M Irgens
Jun 9, 1998·Journal of Reproductive Immunology·D S Dizon-TownsonK Ward
Jul 8, 1998·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S MimuroB Trudinger
Jul 11, 1998·Journal of Clinical Pathology·B NagyT Tóth
Jan 8, 1999·The New England Journal of Medicine·M J KupfermincJ B Lessing
Jan 12, 1999·British Journal of Obstetrics and Gynaecology·A M LachmeijerG A Dekker
Apr 17, 1999·Journal of the Society for Gynecologic Investigation·R W PowersJ M Roberts
Jun 3, 1999·The New England Journal of Medicine·J A IbdahA W Strauss
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·J G Thornton, A M Macdonald
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·L MorganN Kalsheker
Aug 11, 1999·Human Molecular Genetics·R ArngrímssonK Stefánsson
Sep 1, 1999·Epidemiology·I MogrenH Stenlund
Oct 16, 1999·American Journal of Obstetrics and Gynecology·C J De GrootF R Rosendaal
Nov 5, 1999·British Journal of Obstetrics and Gynaecology·A B ChikosiL Rom
Dec 10, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Y SuzukiK Suzumori
Jan 27, 2000·Human Genetics·G GuoS P Brennecke

❮ Previous
Next ❯

Citations

Jun 3, 2010·Archives of Gynecology and Obstetrics·Zahra AnvarMostafa Saadat
Jun 12, 2012·Journal of Pregnancy·Reem MustafaRocco C Venuto
Jul 25, 2014·PloS One·Penghua YangToshihiko Ezashi
Nov 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Yves GiguèreJean-Claude Forest
Nov 22, 2008·Journal of Perinatal Medicine·Chengjuan SunSong Yu
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Paula Juliet Williams, Linda Morgan
Aug 9, 2011·Vascular Health and Risk Management·Jennifer UzanJean-Marc Ayoubi
Feb 19, 2014·Gynécologie, obstétrique & fertilité·C GeylP Deruelle
Oct 12, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y H LeeG G Song
Nov 17, 2015·American Journal of Obstetrics and Gynecology·Agata SakowiczLidia Biesiada
Aug 10, 2013·Advances in Chronic Kidney Disease·Mary L Rosser, Nadine T Katz
Oct 31, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ulrich Abildgaard, Ketil Heimdal
Oct 9, 2009·American Journal of Reproductive Immunology : AJRI·Leea Keski-NisulaJuha Pekkanen
Sep 24, 2010·Annals of the New York Academy of Sciences·Bernard J Crespi
Sep 28, 2010·The Journal of Obstetrics and Gynaecology Research·Giovanni LarcipreteElio Cirese
Jun 9, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Jacob A LykkeJens Langhoff-Roos
May 14, 2011·The Journal of Obstetrics and Gynaecology Research·Shagun AggarwalSarita Agarwal
Apr 8, 2014·American Journal of Reproductive Immunology : AJRI·Quaker E HarmonAndrew F Olshan
Mar 31, 2016·Fertility and Sterility·Hélène LeturJacques de Mouzon
Jul 13, 2013·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·James S BetoniGerard Tromp
Aug 15, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Helen L BarrettLeonie K Callaway
Jun 9, 2012·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Reza AhmadiZiba Rahimi
Jul 5, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Linlu ZhaoMichael B Bracken
Dec 7, 2014·Archives of Gynecology and Obstetrics·Saeedeh SalimiFarzaneh Farajian-Mashhadi
Mar 25, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Agnieszka Seremak-MrozikiewiczKrzysztof Drews
Mar 25, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Paula J Williams, Fiona Broughton Pipkin
Jun 29, 2011·Pregnancy Hypertension·Isha Agarwal, S Ananth Karumanchi
Dec 17, 2011·Journal of Pregnancy·Francisco J ValenzuelaSebastián E Illanes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hypertension
James M Roberts, Hilary S Gammill
Nephron. Clinical Practice
Suzanne Baumwell, S Ananth Karumanchi
Science
Christopher W G Redman, Ian L Sargent
© 2021 Meta ULC. All rights reserved