PMID: 1201691Dec 10, 1975Paper

Genes controlling chromosome activity; the role of genes blocking Y-lampbrush loop propagation

Chromosoma
E Lifschytz

Abstract

Characterization of two more X-linked Y-affecting mutations in D. hydei is presented; ms(1) XL24 is less extreme than the previously described mutation, ms(1)XL2, but its general effect on the propagation of Y-lampbrush loops is similar qualitatively; ms(1)XL24 is located at the distal end of the X-chromosome and associated with a suppressor-of-white phenotype. The other X-linked sterile, ms(1)XL4, is the least extreme of the three mutations examined to date. It is recessive, located ca 2 c.o. units to the right of white, and causes different patterns of Y loop response. -- From a comparison of the effects of the three single mutations, as well as from the analysis of the various double-sterile combinations, we surmise that: 1) if specific activator genes for the Y-lampbrush loops do exist, they are not likely to be located on the X-chromosome of Drosophila; 2) every lampbrush loop is composed of several functional repeats, each of which operates when unfolded; 3) the Y-affecting mutations arrest preferentially, but not exclusively or specifically Y-lampbrush loop propagation probably indirectly through their independent metabolic effects. Since the mutations are not specific for germ line cells, and exhibit various pleiotropic...Continue Reading

References

Jan 1, 1973·The Symposium·B I Kiefer
Sep 1, 1974·Genetics·E Lifschytz, D I Lindsley
Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·W HennigO Leoncini
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·E Lifschytz, D L Lindsley
Jan 1, 1969·Genetica·F M van Breugel, H J Bos
Dec 14, 1968·Journal of Molecular Biology·W Hennig

❮ Previous
Next ❯

Citations

Jul 15, 1977·Developmental Biology·E Lifschytz, D Hareven
Jan 1, 1976·Advances in Enzyme Regulation·W Hennig
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T J HulsebosW Hennig
Feb 1, 1987·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Johannes HacksteinMonica Steinmann-Zwicky
May 1, 1990·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Johannes H P HacksteinHelmut Zacharias

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.