Genes don't count

Archives of Surgery
B D ShamesA H Harken

Abstract

It is the regulation of gene expression that determines phenotype and cellular response. Several families of proteins control gene expression in cells and influence the pathogenesis of multiple organ failure, the acute phase response, atherosclerosis, and graft-vs-host disease. Understanding the basics of the regulation of gene transcription will allow the knowledgeable surgeon to target gene expression as a therapeutic modality in multiple diseases. We examine nuclear factor kappa B as an example of a transcription factor that is involved in multiple surgical diseases and has pharmacological inhibitors available to knowledgeable surgeons.

Citations

Sep 2, 2014·Surgery·Amanda GreenAlden H Harken
Feb 28, 2003·Surgery·Jeffrey L Johnson, Alan H Harken
Jan 24, 2007·Journal of Cardiac Surgery·Miriam Kelley BullardAlden Harken
Jul 13, 2000·Critical Care Medicine·B S Cain, T C Tung

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