Genes expressed in cortical neurons--chromatin conformation and DNase I hypersensitive sites

Neurochemical Research
T R Ivanov, I R Brown

Abstract

DNase I sensitivity experiments were performed utilizing DNA probes to genes which are either transcribed in rat cortical neurons (the 68 kDa neurofilament gene and the neuron-specific enolase gene) or are transcriptionally silent (albumin). Results suggest that unlike liver, in which a hierarchy in chromatin conformation exists between transcribed and nontranscribed genes, the majority of protein coding sequences in cortical neurons may be relatively sensitive to nuclease digestion. This supports our previous observation of an increased DNase I sensitivity of total chromatin in cortical neurons. Nuclease sensitivity experiments also revealed the presence of brain-specific DNase I hypersensitive sites associated with the two neuron-specific genes.

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Citations

Jun 1, 1992·Journal of Neuroscience Research·I G JohnstonI R Brown
Apr 11, 1993·Nucleic Acids Research·D CastigliaI Di Liegro
Dec 1, 1994·Neurochemical Research·D CastigliaI Di Liegro
Nov 1, 1992·Neurochemical Research·A CestelliI Di Liegro
Feb 1, 1992·Cellular and Molecular Neurobiology·A CestelliI Di Liegro

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