PMID: 8459223Apr 1, 1993Paper

Genes for interleukin 7 are transcribed in leukemic cell subsets of individuals with chronic lymphocytic leukemia

The Journal of Experimental Medicine
J FrishmanJ M Plate

Abstract

Regulation of expression of interleukin 7 (IL-7) mRNA is aberrant in the leukemic subset of cells of chronic lymphocytic leukemia (CLL) patients. The entire coding sequence for IL-7 as well as an alternatively spliced IL-7 mRNA are transcribed in these leukemic cells. No IL-7 mRNA expression is detected in fresh peripheral blood mononuclear cells from normal individuals. Furthermore, the "normal" nonleukemic subsets of cells isolated from the same CLL patients also do not express IL-7 mRNA. The only subset of cells in which IL-7 mRNA is detected is the one that contains the leukemic cells themselves. The polymerase chain reaction was used to examine cytokine expression, and flow cytometry was used to purify the various subsets of peripheral blood mononuclear cells examined in these studies, as well as to examine IL-7 receptor expression. A proportion of the cells from the CLL patients express receptors that are capable of binding IL-7, whereas T cell-depleted normal cell preparations do not express receptors for IL-7 that are detectable with IL-7 fluorokines. The IL-7 receptor-bearing cells in CLL patients include a portion of leukemic cells and a fraction of the T cells, as well as some non-T, non-B cells. These findings sugge...Continue Reading

References

Dec 1, 1991·The Journal of Experimental Medicine·H HockT Blankenstein
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P D EnnisP Parham
Jul 1, 1985·Annals of Internal Medicine·R P Gale, K A Foon
Jan 1, 1989·The Journal of Experimental Medicine·Z M SthoegerN Chiorazzi
Jan 1, 1989·Annual Review of Immunology·P Casali, A L Notkins
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G GoodwinA E Namen
May 1, 1989·Immunology Today·C S Henney
Feb 1, 1989·British Journal of Haematology·T HahnA Berrebi
Oct 1, 1986·Immunological Reviews·N Gadol, K A Ault
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A M StallL A Herzenberg
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M L ClearyJ Sklar
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaL A Herzenberg

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Citations

Nov 14, 1997·Cancer Immunology, Immunotherapy : CII·M C AhnD P Braun
May 5, 2005·Bioorganic & Medicinal Chemistry·Ling GuBenjamin E Rich
Dec 14, 2012·Advances in Biological Regulation·Daniel RibeiroJoão T Barata
Jan 1, 1997·Life Sciences·S P Atamas
Mar 14, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·John W OrtegelDonald P Braun
Jun 24, 1999·Cytokine & Growth Factor Reviews·R HofmeisterS K Durum
May 5, 2005·Oncogene·Ninan AbrahamMark A Goldsmith
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·B W LongJ M Plate
Dec 1, 1995·British Journal of Haematology·T Lavabre-BertrandJ Brochier
Jun 1, 1996·Experimental Dermatology·P MöllerD Schadendorf
Jan 12, 2005·Arthritis Research & Therapy·Frederique PonchelJohn D Isaacs
Feb 14, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A A Al-RawiW G Jiang
Dec 19, 2008·Genes and Immunity·N K VudattuM J Maeurer
Jan 27, 2010·International Reviews of Immunology·Anupama Sahoo, Sin-Hyeog Im
Oct 17, 2012·Human Pathology·Min Sung KimSug Hyung Lee
Jan 13, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jian MingEnhua Wang
Aug 11, 2004·Best Practice & Research. Clinical Haematology·John D Isaacs, Andreas Thiel
Oct 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·T TakakuwaK Aozasa
Nov 21, 2019·Nature Immunology·João T BarataBenedict Seddon
Jan 13, 2004·The British Journal of Surgery·M A A Al-RawiW G Jiang

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