Genes for RNA-binding proteins involved in neural-specific functions and diseases are downregulated in Rubinstein-Taybi iNeurons.

Neural Regeneration Research
Lidia LarizzaSilvia Russo

Abstract

Taking advantage of the fast-growing knowledge of RNA-binding proteins (RBPs) we review the signature of downregulated genes for RBPs in the transcriptome of induced pluripotent stem cell neurons (iNeurons) modelling the neurodevelopmental Rubinstein Taybi Syndrome (RSTS) caused by mutations in the genes encoding CBP/p300 acetyltransferases. We discuss top and functionally connected downregulated genes sorted to "RNA processing" and "Ribonucleoprotein complex biogenesis" Gene Ontology clusters. The first set of downregulated RBPs includes members of hnRNHP (A1, A2B1, D, G, H2-H1, MAGOHB, PAPBC), core subunits of U small nuclear ribonucleoproteins and Serine-Arginine splicing regulators families, acting in precursor messenger RNA alternative splicing and processing. Consistent with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4 (SRRM4) protein, the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons, RSTS iNeurons show downregulated genes for proteins impacting this network. We link downregulated genes to neurological disorders including the new HNRNPH1-related intellectual disability syndrome with clinical overlap to RSTS....Continue Reading

References

Apr 11, 2006·RNA·Qing-Shuo ZhangAdrian R Krainer
Jul 27, 2006·European Journal of Human Genetics : EJHG·Raoul C M Hennekam
May 24, 2007·Nature Reviews. Molecular Cell Biology·François-Michel BoisvertAngus I Lamond
Sep 13, 2007·Nature Reviews. Neuroscience·Clive R Bramham, David G Wells
Jul 4, 2008·Trends in Genetics : TIG·Kiven E LukongStéphane Richard
Nov 4, 2008·Nature·Eric T WangChristopher B Burge
Jan 30, 2010·Epigenetics : Official Journal of the DNA Methylation Society·David C BedfordPaul K Brindle
Feb 6, 2010·Science·Reini F LucoTom Misteli
Aug 28, 2010·The Biochemical Journal·Siew Ping HanRoss Smith
Jan 11, 2011·Cell·Reini F LucoTom Misteli
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luis M ValorAngel Barco
Nov 9, 2011·Wiley Interdisciplinary Reviews. RNA·Nicholas J Watkins, Markus T Bohnsack
Apr 5, 2012·Biochemistry·Clarisse van der FeltzDaniel A Pomeranz Krummel
May 3, 2013·Neurology·Michael BenatarJ Paul Taylor
Sep 26, 2013·International Journal of Molecular Sciences·Jacques Jean-PhilippeMassimo Caputi
Apr 29, 2014·Genesis : the Journal of Genetics and Development·John J McMahonDebra L Silver
Sep 10, 2014·Advances in Experimental Medicine and Biology·Stefanie GerstbergerThomas Tuschl
Nov 5, 2014·Nature Reviews. Genetics·Stefanie GerstbergerThomas Tuschl
Apr 18, 2015·Genome Research·Eric T WangChristopher B Burge
May 7, 2015·Acta Neuropathologica·Johnathan Cooper-KnockPamela J Shaw
May 20, 2015·Journal of Proteomics·Yaseswini NeelamrajuSarath Chandra Janga
Sep 1, 2015·Cell·Claudio R AlarcónSohail F Tavazoie
Sep 24, 2015·Nature Reviews. Molecular Cell Biology·Søren Lykke-Andersen, Torben Heick Jensen
Mar 15, 2016·Brain Research·Amy E Brinegar, Thomas A Cooper
Apr 28, 2016·Cell Reports·Ioannis GrammatikakisMyriam Gorospe
May 25, 2016·Human Genetics·Thomas GeuensVincent Timmerman
Aug 23, 2016·American Journal of Human Genetics·Jennifer M BainWendy K Chung
Sep 14, 2016·Wiley Interdisciplinary Reviews. RNA·Elizabeth J F WhiteGerald M Wilson
Apr 9, 2017·The Biochemical Journal·Alice Ford Harrison, James Shorter
Aug 2, 2017·ELife·Whitney L JohnsonAaron F Straight
Sep 12, 2017·RNA Biology·Daniel A Bose, Shelley L Berger
Jan 18, 2018·Nature Reviews. Molecular Cell Biology·Matthias W HentzeThomas Preiss

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Fate Conversion By mRNA

mRNA-based technology is being studied as a potential technology that could be used to reprogram cell fate. This technique provides the potential to generate safe reprogrammed cells that can be used for clinical applications. Here is the latest research on cell fate conversion by mRNA.