PMID: 8580998Jan 1, 1995Paper

Genes involved in testicular development and function

World Journal of Urology
D J Lamb

Abstract

The development of the testis requires the highly regulated expression of a series of genes. Many of the genes involved are transcription factors, such as steroid hormone receptors and growth factors. Investigators have used gene cloning, mutation analysis, transgenic mice, and gene-deletion studies to define the role of specific genes in testicular development and function. In the past 5 years, investigators have defined a gene on the Y chromosome, SRY, thought to be required for testis determination. This protein is a member of a larger family of related transcription factors. Expression of this gene triggers a cascade of events that leads to the development of the Sertoli cell, Leydig cells, and the testis. The development of the male phenotype is dependent on the presence and action of androgens, which exert their effect after combining with a receptor in the nucleus of the target cell that stimulates gene transcription. Defects in the androgen receptor gene lead to a full spectrum of morphological defects in the male. Interestingly, mutations in other members of the steroid receptor superfamily, such as the estrogen receptor gene, also affect male fertility. A number of "orphan" receptors (i.e., receptors whose ligans have...Continue Reading

Citations

Nov 2, 2001·Biochemical and Biophysical Research Communications·A ScheepersA Schürmann
Aug 1, 1998·Biological Chemistry·P SteinertL Flohé
Apr 1, 1997·The Journal of Urology·J S WienerD J Lamb
Oct 16, 2004·The Prostate·Liang WangChawnshang Chang
Oct 24, 2020·Differentiation; Research in Biological Diversity·Laurence BaskinGerald R Cunha

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