May 16, 2001

Genes lost and genes found: evolution of bacterial pathogenesis and symbiosis

Science
H Ochman, N A Moran

Abstract

Traditionally, evolutionary biologists have viewed mutations within individual genes as the major source of phenotypic variation leading to adaptation through natural selection, and ultimately generating diversity among species. Although such processes must contribute to the initial development of gene functions and their subsequent fine-tuning, changes in genome repertoire, occurring through gene acquisition and deletion, are the major events underlying the emergence and evolution of bacterial pathogens and symbionts. Furthermore, pathogens and symbionts depend on similar mechanisms for interacting with hosts and show parallel trends in genome evolution.

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Mentioned in this Paper

Pathogenic Aspects
Mutualism
Pathogenesis
Pathogenicity
Gene Deletion Abnormality
Deletion Mutation
Genes, Bacterial
Recombination, Interspecies
Genome, Bacterial
Biological Evolution

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