Genes, models and Alzheimer's disease

Trends in Genetics : TIG
P F ChapmanM F Ramsay

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that is claiming an increasing number of victims as the world population ages. The identification of gene mutations and polymorphisms that either cause AD or significantly increase the risk for developing it enabled the creation of a whole generation of realistic rodent models of the disease. Animals expressing mutated human amyloid precursor protein and presenilin 1 show dramatic parallels to AD, although none of the models appear to capture the full range of pathologies that characterize the human disease. Increased refinement of these models will enhance the already tantalizing possibility of treatment.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A KammesheidtR L Neve
Aug 18, 1995·Science·E Levy-LahadG D Schellenberg
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·P M MoranP C Moser
Apr 1, 1994·Current Opinion in Lipidology·K H WeisgraberW J Strittmatter
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B E Pearson, T K Choi
Dec 1, 1995·Human Molecular Genetics·D CampionS Tardieu
Jul 1, 1996·Human Molecular Genetics·R SherringtonP H St George-Hyslop
Jul 1, 1997·Brain Research. Molecular Brain Research·C CzechG Tremp
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·C Sturchler-PierratB Sommer
Apr 8, 1998·Annual Review of Neuroscience·D L Price, S S Sisodia
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Y HsiaL Mucke
Mar 15, 2000·Annals of Neurology·J A NicollW S Griffin

❮ Previous
Next ❯

Citations

Feb 4, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lynnette J CookDavid C Rubinsztein
Oct 23, 2002·Journal of Neuroscience Research·Bruce Teter, J Wesson Ashford
Aug 18, 2004·Neurobiology of Aging·Christopher JanusDavid Westaway
Jun 27, 2002·Trends in Pharmacological Sciences·Laura GaspariniHuaxi Xu
Jan 22, 2002·Trends in Neurosciences·Amritpal Mudher, Simon Lovestone
Jan 1, 2003·Brain Research Bulletin·T L ButlerK R Pennypacker
Jul 11, 2002·Free Radical Biology & Medicine·Christian Behl, Bernd Moosmann
Jan 28, 2003·Drug Discovery Today·Peter M Mathisen
Jul 10, 2003·Lancet Neurology·Majid HafezparastElizabeth M C Fisher
Feb 12, 2002·Nature Reviews. Genetics·Maja Bućan, Ted Abel
Jan 25, 2003·The European Journal of Neuroscience·Debby Van DamPeter P De Deyn
Apr 4, 2003·The New England Journal of Medicine·Robert L Nussbaum, Christopher E Ellis
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael J RowanRoger Anwyl
Jul 30, 2003·Genes, Brain, and Behavior·J C DodartS M Paul
Jun 28, 2007·Expert Opinion on Investigational Drugs·Jochen Klein
Nov 7, 2001·The Journal of Clinical Investigation·C Dingwall
Jul 19, 2002·BMC Genetics·Gabriele Dekomien, Jörg Thomas Epplen
Dec 1, 2006·Journal of Negative Results in Biomedicine·Tanja LippmannGabriele Dekomien
Feb 12, 2008·Behavioural Brain Research·R M J DeaconJ N P Rawlins
Nov 12, 2013·Neurobiology of Aging·Ikhlas A SindiPeter R Dodd
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Ravi Rajmohan, P Hemachandra Reddy
Oct 22, 2016·Angewandte Chemie·Jessica Z ChanMasayuki Wasa
May 13, 2004·Expert Review of Molecular Diagnostics·Mohammad Ali FaghihiClaes Wahlestedt
Jan 9, 2010·Biochimica Et Biophysica Acta·Tsu Tshen Chuang
Feb 15, 2005·Neurobiology of Aging·Domenico Praticò
Jul 10, 2001·Aging : Clinical and Experimental Research·C FranceschiM Bonafè
Nov 28, 2002·Annals of Medicine·Ramón Cacabelos
May 20, 2003·CNS Drugs·Christopher Janus

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.