PMID: 16632098DOI: 10.1016/j.ecl.2006.02.008Apr 25, 2006Paper
Genes of type 2 diabetes in beta cells
Endocrinology and Metabolism Clinics of North America
Mirko TrajkovskiMichele Solimena
Abstract
Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.
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