Genes of type 2 diabetes in beta cells

Endocrinology and Metabolism Clinics of North America
Mirko TrajkovskiMichele Solimena

Abstract

Type 2 diabetes is a complex polygenic metabolic disorder of epidemic proportions. This review provides a brief overview of the susceptibility genes in type 2 diabetes that primarily affect pancreatic 3 cells, with emphasis on their function and most relevant polymorphisms. We focus on calpain 10, the only susceptibility gene identified thus far through a positional cloning approach in subjects with diabetes.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S P SmeekensP Gardner
Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P SmeekensD F Steiner
Aug 1, 1985·Molecular and Cellular Biology·M B SoaresA Efstratiadis
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·S I TaylorM J Elders
Jul 1, 1985·The Journal of Clinical Investigation·Y ShibasakiF Takaku
Jul 1, 1982·Clinical Endocrinology·C E LemeJ L Borges
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Q X HuaM A Weiss
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Stoffel, S A Duncan
Feb 7, 1998·The Biochemical Journal·H SorimachiK Suzuki
Jun 27, 1998·Biochemical and Biophysical Research Communications·E Carafoli, M Molinari
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·Q X HuaM A Weiss
Oct 6, 2000·The Journal of Clinical Investigation·L J BaierC Bogardus
May 1, 2001·Journal of Biochemistry·H Sorimachi, K Suzuki
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Aug 2, 2001·American Journal of Human Genetics·J C EvansA T Hattersley
Aug 23, 2001·Trends in Molecular Medicine·Y Huang, K K Wang
Aug 28, 2001·Diabetes·S K SreenanK S Polonsky
Nov 13, 2001·American Journal of Human Genetics·H J TsaiR Deka
Jan 5, 2002·Diabetes·Michael J GarantUNKNOWN Atherosclerosis Risk in Communities Study

❮ Previous
Next ❯

Citations

Jan 5, 2008·Current Diabetes Reports·Peter E H SchwarzJaakko Tuomilehto
Jul 2, 2010·Journal of Cardiovascular Translational Research·Shamjeet SinghPawan K Singal
Dec 25, 2008·The Journal of Clinical Endocrinology and Metabolism·Peter E H SchwarzJaana Lindström
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.