Genes regulating touch cell development in Caenorhabditis elegans.

Genetics
H Du, M Chalfie

Abstract

To identify genes regulating the development of the six touch receptor neurons, we screened the F(2) progeny of mutated animals expressing an integrated mec-2::gfp transgene that is expressed mainly in these touch cells. From 2638 mutated haploid genomes, we obtained 11 mutations representing 11 genes that affected the production, migration, or outgrowth of the touch cells. Eight of these mutations were in known genes, and 2 defined new genes (mig-21 and vab-15). The mig-21 mutation is the first known to affect the asymmetry of the migrations of Q neuroblasts, the cells that give rise to two of the six touch cells. vab-15 is a msh-like homeobox gene that appears to be needed for the proper production of touch cell precursors, since vab-15 animals lacked the four more posterior touch cells. The remaining touch cells (the ALM cells) were present but mispositioned. A similar touch cell phenotype is produced by mutations in lin-32. A more severe phenotype; i.e., animals often lacked ALM cells, was seen in lin-32 vab-15 double mutants, suggesting that these genes acted redundantly in ALM differentiation. In addition to the touch cell abnormalities, vab-15 animals variably exhibit embryonic or larval lethality, cell degenerations, ma...Continue Reading

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Citations

Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Jun 28, 2005·Developmental Biology·Harald HutterEdward M Hedgecock
Feb 8, 2007·Pflügers Archiv : European journal of physiology·Alexander Bounoutas, Martin Chalfie
Jan 22, 2003·Luminescence : the Journal of Biological and Chemical Luminescence·Yong A YuKerby Oberg
Oct 15, 2019·Developmental Biology·José M Martín-Durán, Andreas Hejnol
Jul 2, 2009·Angewandte Chemie·Martin Chalfie
Jun 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin Chalfie

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