PMID: 8595156Feb 1, 1996Paper

Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells

British Journal of Cancer
G KrupitzaC Dittrich

Abstract

Down-regulation of oncogene expression is one of the hallmarks of the process whereby transformed cells are forced into differentiation and/or growth arrest by potent inducers and therefore can represent an interim end point in cancer treatment. The differentiation inducer sodium butyrate (NaB) arrested growth of N.1 ovarian carcinoma cells and repressed expression of cyclin D1/prad1 and the invasiveness-related protease plasminogen activator-urokinase (plau). This was accompanied by the acquisition of a differentiated morphology, all of which characteristics were maintained as long as N.1 cells were exposed to the inducer. In accordance with a differentiated phenotype was the finding that fibronectin expression was increased significantly. Recently, it was shown that NaB represses the transcription factor c-myc by blocking Ca2+ signals and modulating serine threonine kinase activity. We wanted to investigate NaB-mediated interference on signals contributing to the expression on prad1, plau and growth arrest-specific 6 (gas6). Protein kinase A (PKA) inactivation de-repressed prad1 and plau transcript levels. NaB had onlygeneral but no specific influence on PKA-modulated prad1 and plau expression however. Protein kinase C activa...Continue Reading

Citations

Mar 24, 2017·Cell Death & Disease·Guiling WuYang Yang
Mar 12, 2002·Archives of Pharmacal Research·Adorjan Aszalos
Sep 7, 2002·International Journal of Cancer. Journal International Du Cancer·Erica S DyerMats Ljungman
Jan 1, 1997·Pathology Oncology Research : POR·Adorján Aszalós, Sándor Eckhardt
Jul 31, 2001·The Journal of Biological Chemistry·A DerjugaJ P Th'ng
Aug 16, 2001·Trends in Endocrinology and Metabolism : TEM·O H KrämerT Heinzel
Dec 16, 1998·The Journal of Laboratory and Clinical Medicine·M W PhelanD V Faller
Nov 18, 2008·The International Journal of Biochemistry & Cell Biology·Guoling RenJun Lu

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