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Genes required for mycobacterial growth defined by high density mutagenesis

Molecular Microbiology

Mar 27, 2003

Christopher M SassettiEric J Rubin

Abstract

Despite over a century of research, tuberculosis remains a leading cause of infectious death worldwide. Faced with increasing rates of drug resistance, the identification of genes that are required for the growth of this organism should provide new targets for the design of antimycobact...read more

Mentioned in this Paper

Biochemical Pathway
Abnormal Degeneration
Tuberculosis
TraSH (Transposon Site Hybridization)
Genes, Bacterial
Organism
Mycobacterium tuberculosis H37Rv
Mycobacterium leprae (bacteria)
Mutagenesis Procedure
Drug Resistance
15
819
1
Paper Details
References
  • References19
  • Citations1152
12
  • References19
  • Citations1152
12345...

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Genes required for mycobacterial growth defined by high density mutagenesis

Molecular Microbiology

Mar 27, 2003

Christopher M SassettiEric J Rubin

PMID: 12657046

DOI: 10.1046/j.1365-2958.2003.03425.x

Abstract

Despite over a century of research, tuberculosis remains a leading cause of infectious death worldwide. Faced with increasing rates of drug resistance, the identification of genes that are required for the growth of this organism should provide new targets for the design of antimycobact...read more

Mentioned in this Paper

Biochemical Pathway
Abnormal Degeneration
Tuberculosis
TraSH (Transposon Site Hybridization)
Genes, Bacterial
Organism
Mycobacterium tuberculosis H37Rv
Mycobacterium leprae (bacteria)
Mutagenesis Procedure
Drug Resistance
15
819
1

Similar Papers Found In These Feeds

Leprosy

Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacteria Mycobacterium leprae or Mycobacterium lepromatosis. Infection can lead to damage of the nerves, respiratory tract, skin, and eyes. This damage may result in a lack of ability to feel pain, which can lead to the loss of parts of extremities from repeated injuries or infection due to unnoticed wounds. Discover the latest research on leprosy here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America

Genetic requirements for mycobacterial survival during infection

Proceedings of the National Academy of Sciences of the United States of AmericaOctober 22, 2003
Christopher M Sassetti, Eric J Rubin
Paper Details
References
  • References19
  • Citations1152
12
  • References19
  • Citations1152
12345...
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